conclusions use of ha in an algorithm model, is an extra and valuable tool for assessing liver necro inflammatory injuries- in parallel with liver biopsy- but more comprehensive studies are needed to approve the use of ha as an appropriate clinical tool. results there are several scientific studies indicating ha as a biomarker for high score fibrosis and cirrhosis in various liver diseases alon...

A common single nucleotide polymorphism (SNP), rs6983267, at 8q24.21 has recently been shown to associate with colorectal cancer (CRC). Three independent SNP association studies showed that rs6983267 contributes to CRC with odds ratios (OR) of 1.17 to 1.22. Here, we genotyped a population-based series of 1,042 patients with CRC and 1,012 healthy controls for rs6983267 and determined the contrib...

Hypoxia is a fundamental stimulus that impacts cells, tissues, organs, and physiological systems. The discovery of hypoxia-inducible factor-1 (HIF-1) and subsequent identification of other members of the HIF family of transcriptional activators has provided insight into the molecular underpinnings of oxygen homeostasis. This review focuses on the mechanisms of HIF activation and their roles in ...

OBJECTIVE To demonstrate the effect of hypokinesia (HK) and post-HK on phosphate (Pi) imbalance and use of Pi with different Pi imbalance and different Pi consumption: were measured Pi balance, plasma Pi level and Pi loss during HK. METHODS Experiments were conducted during the pre-experimental period of 30 days, and the HK period of 364-days and post-HK period of 30-days. Forty healthy male ...

Allelic imbalance (AI) encompassing the apoptotic protease-activating factor 1 (APAF-1) locus (12q22-23) is found frequently in metastatic melanoma. Circulating DNA with AI on 12q22-23 in serum was evaluated as a surrogate marker to predict biochemotherapy (BC) treatment response in melanoma patients. Sera were collected from 49 American Joint Committee on Cancer stage IV melanoma patients trea...

PURPOSE Our objective was to determine the risk factors for inpatient admission of pediatric burn patients. MATERIALS & METHODS This cross-sectional study uses data from the Healthcare Cost and Utilization Project Kids' Inpatient Database (HCUP KID) for the years of 2003, 2006, 2009, and 2012 to estimate the risk factors for inpatient admission for pediatric patients who sustained a burn inju...

The mesostriatal dopaminergic system, which comprises the mesolimbic and the nigrostriatal pathways, plays a major role in neural processing underlying motor and limbic functions. Multiple reports suggest that these processes are influenced by hemispheric differences in striatal dopamine (DA) levels, DA turnover and its receptor activity. Here, we review studies which measured the concentration...

1Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China 2Department of Neurology, Xijing Hospital, The Fourth Military Medicine University, Xi’an 710032, China 3School of Dentistry, Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Heath Park, Cardiff CF14 4XY, UK 4Department of Neurology, Henry Ford Hospital, Detroit, MI 482...

In this paper we give a systematic analysis of the relationship between imbalance and overlap as factors influencing classifier performance. We demonstrate that these two factors have interdependent effects and that we cannot form a full understanding of their effects by considering them only in isolation. Although the imbalance problem can be considered a symptom of the small disjuncts problem...

This paper will review literature on Western mediation to determine whether power balance is an issue that is considered in the theoretical literature on this subject. The impact of power imbalance on the mediation process will be discussed. Attention will also be given to the role of mediators and participants in wielding influence over the power dynamic in mediation. The premise that there ar...