Sequence analysis often does not take the physicochemical properties into account. On the other hand, some of these properties could be useful in inferring the folding and functional attributes of the molecule when considered with the original sequence information. We evaluated here an analysis using multiple aligned sequences incorporating five physicochemical properties. In addition to site i...

the inter-tidal mangrove environment of mengkabong lagoon is important as it supports the local fishing activities, nursery grounds for many fish and shellfish species, and as well as being central for ecotourism activities. the study showed that in general, the physicochemical parameters (ph, salinity and electrical conductivity), granulometric fractions, organic matter, base cations (na, k, c...

Which intrinsic biomaterial parameter governs and, if quantitatively monitored, could reveal to us the actual lifetime potential of advanced hip joint bearing materials? An answer to this crucial question is searched for in this paper, which identifies ceramic bearings as the most innovative biomaterials in hip arthroplasty. It is shown that, if in vivo exposures comparable to human lifetimes a...

We describe the molecular dynamics (MD)-aided engineering design of mutant peptides based on the alpha-helical coiled-coil GCN4 leucine zipper peptide (GCN4-p1) in order to obtain environmentally-responsive nanotweezers. The actuation mechanism of the nanotweezers depends on the modification of electrostatic charges on the residues along the length of the coiled coil. Modulating the solution pH...

AbstractMedication errors are commonly encountered in hospital setting. Intravenous medications pose particular risks because of their greater complexity and the multiple steps required in their preparation, administration and monitoring. We aimed to determine the rate of errors during preparation and administration phase of intravenous medications and the correlation of these errors with the d...

The study on physiochemical factors and primary production of the aquatic ecosystems is important to know the characteristic of environment and capacity of recharge. Mahshahr creeks are the most important creeks in Khuzestan, Iran. In this study, variations in physiochemical factors, chl-a and primary production in 3 regions (Mahshahr, Zangi, and Moussa entrance creeks) were evaluated in 2 mont...

One of the most important forms of preharvest damage to wheat is caused by sunn pests. The insects insert their mouth parts into the immature grain and while injecting their saliva suck the milky juices. Flour from damaged wheat results in low baking performance due to the bug proteolytic enzymes’ injected which cause the breakdown of gluten structure in the dough. In the present study three wh...

The physicochemical properties of bovine prothrombin and of bovine thrombin were previously described in this journal (1, 2). A derivative of bovine prothrombin, autoprothrombin II, has now been obtained in sufficient quality and quantity for study. In this report we describe some of the physicochemical properties of our product, including sedimentation coefficient, diffusion coefficient, intri...

Physicochemical properties, such as solubility, are important when prioritising compounds for progression on a drug discovery project. There is limited literature around the systematic effects of core changes thermodynamic solubility. This work details synthesis nitrogen containing 6,5-bicyclic heterocyclic cores which common scaffolds in medicinal chemistry and analysis their physicochemical p...