BACKGROUND AND OBJECTIVES This study compared the training programs and career paths of family medicine graduates in the National Research Service Award (NRSA) Program for Research in Primary Medical Care with general internal medicine and general pediatric peers. METHODS We mailed a survey to NRSA fellows graduating from 23 programs nationally between 1988-1997. Personal characteristics, fel...

The incidence of nasopharyngeal carcinoma (NPC) varies widely according to geographic location and ethnic background. Over the year, numerous studies have shown that the etiology of NPC is multifunctional, including genetic, environmental, and virological factors. Among these factors, EBV seems to be the strong association between infection of EBV and NPC (International Agency for Research on C...

Purpose: Epstein–Barr virus (EBV) infection and a family history of nasopharyngeal carcinoma (NPC) are associated with NPC risk. We examined the risk associated with EBVmarkers and their clinical utility to identify NPC susceptibles within high-risk NPC families. Experimental Design:We evaluated antibody titers against viral capsid antigen (VCA) IgA, EBV nuclear antigen-1 (EBNA1) IgA, andDNase ...

BACKGROUND Nasopharyngeal carcinoma (NPC) is a common malignant tumor observed in the populations of southern China and Southeast Asia. However, little is known about the effects of purinergic signal on the behavior of NPC cells. This study analyzed the effects of ATP on the growth and migration of NPC cells, and further investigated the potential mechanisms during the effects. METHODS Cell v...

BACKGROUND The purpose of this study was to explore the risk of developing of sudden sensorineural hearing loss (SSHL) in patients with nasopharyngeal carcinoma (NPC). METHODS A population-based, retrospective cohort study using the Taiwan National Health Insurance Research Database was conducted. From 2001 to 2006, 9121 patients with newly diagnosed NPC and 45,605 comparison subjects without...

OBJECTIVE To investigate the expression profile and the clinical significance of CDK3 in the tissues of nasopharyngeal carcinoma. METHOD Immunohistochemistry was utilized to detect the expression of CDK3 in 94 cases of NPC and 40 cases of nasopharyngeal inflammation. RESULT CDK3 was highly expressed in NPC cell lines. Immunohistochemistry showed that CDK3 was mostly expressed in the cytopla...

OBJECTIVES To characterize the specific Epstein-Barr virus (EBV) polymorphisms from nasopharyngeal carcinoma (NPC) patients and healthy donors in Northern China, and to explore the relationship between the EBV genotypes and NPC. METHODS The genotypes of EBV strains were analyzed by the polymerase chain reaction and restriction fragment length polymorphism. RESULTS The predominant EBV type w...

BACKGROUND Spleen tyrosine kinase (Syk) is a nonreceptor tyrosine kinase and often aberrantly expressed in human cancers. However, Syk expression pattern has not yet been investigated in nasopharyngeal carcinoma (NPC). METHODS Samples of 223 NPC tissues were immunohistochemically stained for Syk expression and survival analysis was then performed. Interaction and co-localization of Syk with E...

Abstract Introduction Penile duplex Doppler ultrasound (PDDU) is an important test to diagnose and guide treatment recommendations for peyronie’s Disease erectile dysfunction. When patients do not achieve optimal rigidity during their evaluation we may be underestimating degree of curvature erection response which can impact recommendations. Objective To evaluate specific examination conditions...

Background Patient–physician communication during clinical encounters is essential to ensure quality of care. Many studies have attempted improve patient–physician communication. Incorporating patient priorities into agenda setting and medical decision-making are fundamental patient-centered Efficient scalable approaches needed empower patients speak up prepare physicians respond. Leveraging el...