photodynamic therapy (pdt) using 5-aminolevulinic acid (5-ala)-induced protoporphyrin ix (ppix) has been considered as a new method for treating neoplasms. however, ala-pdt is suboptimal for thick tumors. searching for new approaches, we investigated the effect of adding differentiation therapy (dt) with vitamin e succinate (ves) to pdt in human prostate ln-cap-fgc10 cancer cells in vitro . the...

introduction: cutaneous leishmaniasis (cl) is a widespread disease that is epidemic in iran, too. photodynamic therapy (pdt) is an attractive modality to treat cancer and hyper proliferative diseases based on the use of a photosensitizer in the presence of oxygen and proper wavelength of light. in consideration of lesion location, lack of systemic involvement and inefficiency of current treatme...

BACKGROUND Recent years have seen an increase in the off-label use of photodynamic therapy for the treatment of a variety of skin diseases. Plaque-phase mycosis fungoides is among the most promising possibilities for the use of this treatment. OBJECTIVES To evaluate the treatment of plaque-phase mycosis fungoides with photodynamic therapy and compare the results obtained using fluorescence ph...

The photodynamic effects of sulphonated zinc and aluminum phthalocyanine derivatives as well as phosphonated aluminum phthalOcyanine on the firing of isolated crayfish mechanoreceptor neurons were studied. After 30 min staining neurons were irradiated with He-Ne laser (632.8 nm, 0.3 W/cm2) and changes in neuron firing frequency were recorded. Neuron firing was found to be very sensitive to phot...

The literature concerned with photodynamic action is surprisingly reticent upon the subject of the role played by the radiation used to induce the effect. It is tacitly assumed that the radiation,plays its part solely via the so-called 'sensitizing' agent. The possibility of direct action upon the test material appears to have been ignored. Recently (Calcutt, 1950), evidence has been put forwar...

Photodynamic therapy combining nanotechnology has shown great potential with improved therapeutic efficacy and fewer side effects. Ideal photosensitizers for cancer treatment should both have good singlet oxygen production capability and be excitable by light illuminations with deep tissue penetration. Here we report a type of hybrid photosensitizers consisting of plasmonic silver nanoparticles...

Periodontal disease is a multifactorial disease associated with destruction of supporting periodontal tissues of the tooth caused by certain periodontopathogenic species of bacteria or their toxic products by means of a biofilm formation. The conventional methods to treat periodontal diseases are the mechanical removal of the biofilm and adjunctive use of antibacterial disinfectants or various ...

The present report is on a 67-year-old man with stage IV small cell lung cancer and early-stage centrally located squamous cell cancer of the lung. He was diagnosed as small cell lung cancer with multiple metastasis to the ipsilateral lung and was found to have a central-type early-stage squamous cell cancer by bronchoscope. After obtaining a complete response to the small cell lung cancer with...

Minimization or elimination of antibiotic resistance in microbial species is an urgent need of the present times. Antimicrobial photodynamic therapy is a new therapeutic option through which development of resistance in microorganisms can be avoided. Interest in the use of photodynamic therapy to combat microbial infection is not only linked to the fact that this technique prevents antibiotic r...

Although introduced for the treatment of maculopathies, photodynamic therapy (PDT) is now largely used in some eye cancers treatment. The selective tissue damage with PDT is achieved by sequestration of the photosensitizer in the target tissue and focal activation of the photosensitizer by low energy directed light. In this way, it is possible to achieve the destruction of the tumor tissue by s...