نتایج جستجو برای: phic31 intagrase

تعداد نتایج: 153  

2015
Minsi Zhang David G. Kirsch

Novel genetically engineered mouse models using the Cre-loxP or the Flp-FRT systems have generated useful reagents to manipulate the mouse genome in a temporally-regulated and tissue specific manner. By incorporating a constitutive Cre driver line into a mouse model in which FRT-regulated genes in other cells types are regulated by Flp-FRT recombinase, gene expression can be manipulated simulta...

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2014
Robert J. Yamulla Eric G. Kane Alexandra E. Moody Kristin A. Politi Nicole E. Lock Andrew V. A. Foley David M. Roberts

The Wnt pathway is a conserved signal transduction pathway that contributes to normal development and adult homeostasis, but is also misregulated in human diseases such as cancer. The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator of Wnt signaling inactivated in.80% of colorectal cancers. APC participates in a multiprotein “destruction complex” that targets...

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2015
Vincent Panneton Apurba Nath Fadi Sader Nathalie Delaunay Ariane Pelletier Dominic Maier Karen Oh David R. Hipfner

Protein kinases carry out important functions in cells both by phosphorylating substrates and by means of regulated noncatalytic activities. Such non-catalytic functions have been ascribed to many kinases, including some members of the Ste20 family. The Drosophila Ste20 kinase Slik phosphorylates and activates Moesin in developing epithelial tissues to promote epithelial tissue integrity. It al...

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