A sensitivemethod for the detection of ceruloplasmin (ferroxidase) in human serums, using Fe(Il) as the substrate, is described. Initial Fe(ll) concentrations of 30 and 120 p.M may be used, depending on the sensitivity of the spectrophotometer, for the determination of the rate of Fe(Ill) -transferrin formation following the oxidation of Fe(lI) by ceruloplasmin (ferroxidase). Advantages of this...

Using HPLC a fraction of New Zealand manuka honey has been isolated, which gives rise to the non-peroxide antibacterial activity. This fraction proved to be methylglyoxal, a highly reactive precursor in the formation of advanced glycation endproducts (AGEs). Methylglyoxal concentrations in 49 manuka and 34 non-manuka honey samples were determined using a direct detection method and compared wit...

We report a Cu-catalyzed coupling between triarylaluminum reagents and alkyl halides to form arylalkanes. The reaction proceeds in the presence of N,N,N',N'-tetramethyl-o-phenylenediamine (NN-1) as a ligand in combination with CuI as a catalyst. This catalyst system enables the coupling of primary alkyl iodides and bromides with electron-neutral and electron-rich triarylaluminum reagents and af...

Allergic Contact Dermatitis to p-phenylenediamine and Some of its Reaction Products E. Young*, E. Zimerson, C. Svedman, M. Bruze Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden *Corresponding author: Dr. Ewa Young Department of Occupational and Environmental Dermatology Skåne University Hospital 205 02 Malmö, Sweden, Tel: +46-4...

Economic and environmentally friendly bio-mimetic one-pot three and four-component Knoevenagel-hydrogenation (K-H), five-component Knoevenagel-hydrogenation-alkylation (K-H-A) and six-component Knoevenagel-hydrogenation-alkylation-Huisgen cycloaddition (K-H-A-HC) reactions of aldehydes, CH-acids, o-phenylenediamine, alkyl halides and azides using proline, proline-metal carbonate and proline-met...

Eli Lilly EL-468, a phenylenediamine, possesses the delayed-toxicity necessary for a bait toxicant to control colonies of the red imported fire ant, Solenopsis invicta Buren. In laboratory tests it gave delayed action over more than a 10-fold range of concentrations; in field tests, baits formulated on pregel defatted corn grits and applied at 20 and 40 g AI/ha produced as high as 86 and 91% co...

The rate of the degenerate isomerization of A^-hexafluoroisopropylidene-V,V-dimethyl-/?-phenylenediamine was measured by high-pressure F NMR spectroscopy in a viscous hydrocarbon, 2,4-dicyclohexyl-2-methylpentane. Pressure-induced retardations that cannot be rationalized within the framework of the transition state theory (TST) were observed, and it was concluded that the reaction was cast into...

A novel iron(III) complex [Fe(SF)](ClO(4))(3).2H(2)O; in which SF = N,N(0)-bis{5-[(triphenylphosphonium chloride)-methyl] salicylidene}-o-phenylenediamine) has been synthesized and characterized using different physicochemical methods. The binding of this complex with calf thymus (CT) DNA was investigated by circular dichroism, absorption studies, emission spectroscopy, voltammetric studies, an...

P2O5-SiO2 (30% w/w) was found to be a useful catalyst for the synthesis of various 2-substituted aryl benzimidazoles under solvent-less and in solvent conditions from o-phenylenediamine and aldehydes. The products were directly recrystallized from methanol.

An efficient one-pot oxidation/condensation tandem process has been developed for the synthesis of 2-substituted benzimidazole derivatives from benzylic alcohols and 1,2-phenylenediamine with use of urea-hydrogen peroxide/silica phosphoric acid  as a bifunctional catalyst. This method provides a rapid and efficient access to 2-substituted benzimidazoles.