L-Phenylalanine is one of the essential amino acids that cannot be synthesized in mammals in adequate amounts to meet the requirements for protein synthesis. Fungi and plants are able to synthesize phenylalanine via the shikimic acid pathway. L-Phenylalanine, derived from the shikimic acid pathway, is used directly for protein synthesis in plants or metabolized through the phenylpropanoid pathw...

Phenylalanine transfer RNA (tRNA) from Ehrlich ascites tumor differs chromatographically from phenylalanine tRNA isolated from various organ sources. This paper reports studies undertaken to examine the biologic role of the altered tRNA. No differences were detected in the binding of phenylalanine tRNA from tumor or normal tissue to Escherichia coli ribosomes in the presence of synthetic polynu...

Abstract The stability constants of some the binary and ternary system involving Nickel(II) have been studied. Bis-(pyridyl) benzilidene acts as a primary ligand. Glycine, L-alanine, L-phenylalanine, L-leucine L-valine were secondary complex are calculated by SCOGS computer program. reported values ± 0.02 log unit accuracy. protonation increase with an increasing percentage dimethyl sulphoxide....

Aspartame (N-aspartyl-phenylalanine methyl ester), a widely used artificial sweetener, is hydrolyzed in the intestinal lumen to methanol and to its constituent amino .acids phenylalanine and aspartic acid. Ingestion of this sweetener causes a sharp increase in plasma phenylalanine I vels in normal persons. and in patients with phenylketonu ia.2The label on aspartame-containing products includes...

The effects of large doses of L-phenylalanine and of aspartame on seizure susceptibility and severity have been assessed in baboons Papio papio from Senegal which show photosensitive epileptic responses similar to primary generalised epilepsy in man. L-Phenylalanine, 50, 150 or 450 mg/kg, or aspartame, 300 or 1000 mg/kg, were administered orally. Peak plasma L-phenylalanine concentrations of ap...

Although with early treatment phenylketonuria patients may have average intelligence levels, it is important to optimize the nutritional management to maintain adequate phenylalanine levels, so that patients can develop their intellectal potential free of abnormalities in their daily activities due to deficits of cognitive executive functions. This study presents a series of 26 patients, diagno...

The enzymic hydroxylation of phenylalanine by phenylalanine hydroxylase (E.C. 1.14.16.1.) in vitro is dependent on the presence of hydrogen peroxide removing processes. The loss of phenylalanine hydroxylase activity can be prevented to the same extent by catalase as well as the presence of optimized amounts of both peroxidase and superoxide dismutase. Peroxidase alone exhibited only two third o...

Phenylalanine Ammonia-Lyase, L-ar-Aminooxy-/?-phenylpropionic Acid, Aromatic Amino Acids, Shikimic Acid, Fagopyrum esculentum L-a-Aminooxy-/?-phenylpropionic acid (AOPP), a potent competitive inhibitor of phenylalanine ammonia-lyase (PAL), blocked light-induced phenylpropanoid synthesis in excised buckwheat hypocotyls and produced an up to 40-fold increase in the endogenous phenylalanine concen...

The usual treatment for phenylketonuria (PKU) is a phenylalanine-restricted diet. Following this diet is challenging, and long-term adherence (and hence metabolic control) is commonly poor. Patients with PKU (usually, but not exclusively, with a relatively mild form of the disorder) who are responsive to treatment with pharmacological doses of tetrahydrobiopterin (BH4) have either lower concent...