Introduction: Recent research has reported the cytotoxic potential of hydrazones against various strains cancer cells. Aim: To evaluate anticancer activity in vitro and pharmacokinetic profile six synthesized hydrazonic compounds, identified as vanillin 1-phthalazinylhydrazone (VAN-1); 2,4-dinitrophenylhydrazone (VAN-2); phenylhydrazone cinnamaldehyde (CIN-1); isonicotinoyl hydrazone (CIN-2); 1...

objectives: the aim of this research was the development of 111in-labeled porphyrins as possible radiopharmaceuticals for the imaging of tumors. methods: ligands, 5, 10, 15, 20-tetrakis (3, 5-dihydroxyphenyl) porphyrin) (tdhpp), 5, 10, 15, 20-tetrakis (4-hydroxyphenyl) porphyrin (thpp) and 5, 10, 15, 20-tetrakis (3,4-dimethoxyphenyl) porphyrin) (tdmpp) were labeled with 111incl3 (produced from ...

The antimycotic activity of 16 o-nitrophenylhydrazones against strains of Hansenula anomala, Saccharomyces cerevisiae, Candida parapsylosis, and Cryptococcus albidus was tested. All 16 compounds inhibited growth of the yeast strains. The inhibitory activity of the 4 methyl-derivatives substituted on the aromatic nucleus was particularly significant.

Molecules containing carbon–nitrogen double bonds are prevalent in both chemical and biological contexts. The foundations for our current understanding of carbon–nitrogen double-bond formation and hydrolysis were laid by seminal work on hydrazone hydrolysis and formation, and by contributions from mechanistic studies on enzymes that utilize pyridoxal phosphate. In particular, the meticulous kin...

Abstract. Biotransformations are chemical reactions carried out by microorganisms on organic substrates. can be regio-, chemo-, stereo- and enantio-selective. Bioreductions of great interest to the food pharmaceutical industries as they help reduce costs impacts environment. In this work, following biotransformations chalcones were performed: (2E)-1-(4-hydroxy-phenyl)-3-(2-methoxy-phenyl)-prop-...

“Malaria” is a life-threatening blood disease in tropical regions that spreads by the bite of the Anopheles mosquito. Antimalarial medications are designed to cure or prevent this infection, and prosperous achievements in this area mostly depend on the knowing the drug-receptor interactions and active sites of medicine. This improvement can be achieved through understanding the electronic struc...

In the title compound, C(11)H(15)N(3)O(3)S, the C-S-N(H)-N linkage is nonplanar, the torsion angle being 75.70 (12)°. The compound has two almost planar fragments linked to the S atom: the hydrazone-derivative fragment [(HONC(4)H(6))N-N(H)-] and the tolyl fragment (C(7)H(7)-) have maximum deviations from the mean plane through the non-H atoms of 0.0260 (10) and 0.0148 (14) Å, respectively. The ...

Thermodynamic control over kinetically-trapped mixtures of hydrazone-based macrocycles is achieved by addition of an aromatic monohydrazide to generate dynamic combinatorial libraries (DCLs) of linear and macrocyclic oligomers.