The HMGA1 and HMGA2 genes code for proteins belonging to the High Mobility Group A family. Several genes are negatively or positively regulated by both these proteins, but a number of genes are specifically regulated by only one of them. Indeed, knock-out of the Hmga1 and Hmga2 genes leads to different phenotypes: cardiac hypertrophy and type 2 diabetes in the former case, and a large reduction...

Vegetable fats and oils are major sources of dietary vitamin E. Consequently the current trend to reduce fat consumption is accompanied by a reduction of the intake of vitamin E. In addition, the absorption of vitamin E is thought to be dependent on the hydrolysis of dietary lipids in the small intestine. It is therefore conceivable that a lower dietary fat intake also diminishes the intestinal...

This study was designed to test the influence of dietary calcium and vitamin D levels on the promotional effect of high-fat diets on chemically induced mammary carcinogenesis. In a small preliminary experiment (Experiment A), 40 female Sprague-Dawley rats, 43 days old, were randomly divided into 5 groups (8 rats/group) and fed a semipurified diet containing 3% sunflower seed oil (SF) by weight,...

BACKGROUND Interindividual differences in the bioavailability of potentially carcinogenic estrogen and estrogen metabolites (EMs) may play a role in the risk of breast cancer. OBJECTIVE We examined whether dietary intakes of fiber and fat influence premenopausal EM profiles through effects on estrogen synthesis, metabolism, or excretion. METHODS We conducted a cross-sectional analysis of 59...

BMI or waist girth (1,2), these measures of body fat are relatively imprecise, and residual confounding is possible. In the current study, the more precise DEXA scanning method was used to measure body fat and trunk fat. These DEXA measures correlated more strongly than BMI with both CRP levels and physical fitness. A limitation of the current study was variability in serum CRP levels. This var...

Background: Reducing uric acid (UA) levels can provide some improvements in terms of the development risk and course various diseases. Early diagnosis treatment UA elevation have become an important research area recent years. Objectives: The present study aimed to investigate relationship between diets change serum after with different carbohydrate, fat ratios were applied male female patients...

Genetic and phenotypic parameters for production traits and somatic cell count (SCC) for Jersey dairy cattle in Zimbabwe were estimated. A total of 10986 lactation records were obtained from Zimbabwe Livestock Identification Trust, with cows calving in the period from 1996 to 2008. An ASReml program fitting an animal model was used for the analyses. Heritability estimates for milk yield, fat yi...