BACKGROUND The area of biodegradable/sustainable polymers is one of increasing importance in the 21st Century due to their positive environmental characteristics. Lewis acidic metal centres are currently one of the most popular choices for the initiator for the polymerisation. Thus, in this paper we report the synthesis and characterisation of a series of monometallic homopiperazine Ti(IV) comp...

alkylation of biphenyl with 1-octene was investigated using ((al+c3h7cl)+c2h4) catalysts. the catalytic activity of ((al+c3h7cl)+c2h4) for the alkylation was studied at different temperatures, mol ratios of biphenyl to 1-octene, reaction times and catalyst concentrations. it was shown that using this catalyst has more advantagous than another catalysts. experiments show that by increasing tempe...

In continuation of our interest in the synthesis of biologically active, natural and synthetic compounds, we have come across some surprises even with simple reactions like alkylation, condensation and rearrangement, which have resulted in the formation of some unusual novel products. Structures of these were assigned on the basis of their detailed spectral analysis and also confirmed in a few ...

It is shown that bacteria Bradyrhizobium japonicum 273 were capable of degrading phenol at moderate concentrations either in a free cell culture or by immobilized cells on granulated activated carbon particles. The amount degraded was greater an preparation than culture. application constant electric field during cultivation led to enhanced biodegradation and carbon. highest removal efficiency ...

Mannich bases of thymol were synthesized. The aminomethylation reaction was realised in the ortho position of the phenol for compounds 2 (dipropylamine), 3 (benzylamine), and 4 (dibenzylamine) while it was from para position for 1 (dimethylamine), 5 (piperidine), 6 (morpholine) and 7 (N-methylpiperazine). The carbonic anhydrase (CA, EC 4.2.1.1) inhibitory effects of the compounds were asssessed...

Benzene, diphenyl sulfone (DPS), para-hydroxybiphenyl (PPP), ortho-hydroxybiphenyl (OPP), higher hydroxybiphenyls, and alkylated benzenes were found in a small lake receiving contaminated groundwater discharge from the Industri-Plex Superfund site (Woburn, MA) in the Aberjona watershed in eastern Massachusetts. All of these chemicals may derive from the former phenol manufacturing activities pr...

Tri-ortho-cresyl phosphate (T.O.C.P.) is an organic phosphorus compound commonly used in industry as a plasticizer, and is so used in the manufacture of lacquers, dopes, synthetic fabrics, and synthetic lignin resin; it is used as a water-proofing agent in textile manufacture. It is said to be an excellent grinding medium for pigments; it is also used in making polyvinyl chloride sheeting and f...

We present a quantum chemical study of oxidation of phenoxy and benzyl radicals by HO2. All calculations were carried out using the modified Perdew-Wang (MPW1K) density functional method. We found that adsorption of HO2 in the ortho and para positions of the aromatic ring leads to stable phenyl-OOH and benzyl-OOH adducts with dissociation energies from 16 to 27 kcal/mol. Calculations indicate t...

A series of novel 2-(1,3-diaryl- 4,5-dihydro-1H-pyrazol-5-yl)phenol derivatives (C1-C24) have been synthesized. The B-Raf inhibitory activity and anti-proliferation activity of these compounds have been tested. Compound C6 displayed the most potent biological activity against B-RafV600E (IC50 = 0.15 µM) and WM266.4 human melanoma cell line (GI50 = 1.75 µM), being comparable with the positive co...

Glucuronidation is an important pathway for human drug metabolism. Four cloned and expressed human UDP-glucuronosyltransferases (UGT1A1, UGT1A6, UGT1A9, and UGT2B15) were used to screen a series of three potential drug substrates differing only in position of the phenol moiety. The meta and para phenols, UK-156,037 and UK-157,147, were found to be substrates for UGT1A1 with K(m) values of 256 a...