1. In liver microsomal membranes from adult rabbits treated with beta-naphthoflavone, reaction with Cu2+ salts plus 1,10-phenanthroline leads to the cross-linking of the two specifically beta-naphthoflavone-inducible cytochrome P-450 species, form 4 and form 6, to form homo- and hetero-dimer species. 2. The cross-linking is not reversed by treatment with 2-mercaptoethanol, so that it can be obs...

The concentrations of ferrous and ferric ions change dramatically during the course of the batch experiments usually performed to study the kinetics of the bacterial oxidation of ferrous ions and sulfide minerals. This change in concentration of the iron species during the course of the experiment often makes it difficult to interpret the results of these experiments, as is evidenced by the lac...

Cysteine plays a key role as a metal ligand in metalloproteins. In all well-recognized cases, however, it is the anionic cysteinate that coordinates. Several cysteinate-ligated heme proteins are known, but some fail to retain thiolate ligation in the ferrous state, possibly following protonation to form neutral cysteine. Ligation by cysteine thiol in ferrous heme proteins has not been documente...

Porphyria cutanea tarda (PCT) is characterized biochemically by excessive hepatic synthesis and urinary excretion of uroporphyrin I. Clinical evidence has implicated iron in the pathogenesis of PCT. The synthesis of the normally occurring isomer of uroporphyrin, namely uroporphyrin III, from porphobilinogen (PBG) requires two enzymes; uroporphyrinogen I synthetase and uroporphyrinogen III cosyn...

Interest in the aging of metal hydroxide has increased greatly during the past few years and it is due, no doubt, mainly to the fact that certain metal hydroxides have become useful for the isolation of enzymes and vitamins. The selective adsorption properties of these hydroxides, aluminum hydroxide for example, make them suitable for these purposes. Their surface forces make it possible to sep...

the oxidation of ferrous iron (fe2+) in solution using acidithiobacillus ferrooxidans has industrial applications exclusively in the regeneration of ferric iron (fe3+) as an oxidizing agent for the removal of hydrogen sulfide from waste gases, desulfurization of coal, leaching of non-ferrous metallic sulfides and treatment of acid mine drainage. the aim of this investigation was to increase the...

A preorganized tetradentate phenanthroline-derived amide ligand, N,N'-diethyl-N,N'-ditolyl-2,9-dicarboxamide-1,10-phenanthroline (Et-Tol-DAPhen), was found to show high selectivity towards small copper ions, which might be due to the change of the coordination mechanism from tetradentate to terdentate mode.

Rational modification of a natural RNA-binding peptide with a lanthanide EDTA chelator, and a phenanthroline ligand yields a highly selective luminescent sensor. The sensing mechanism relies on the RNA-triggered folding of the peptide into a β-hairpin, which promotes the coordination of the phenanthroline sensitizer, and the efficient sensitization of complexed lanthanide ions.

BACKGROUND Some pregnant women discontinue iron supplements consumption due to Gastrointestinal (GI) complications, whereas pregnancy induces the same complications physiologically. OBJECTIVES The aim of the present study was to assess GI complications of ferrous sulfate in pregnant women. PATIENTS AND METHODS This randomized, double-blind, placebo-controlled clinical trial was performed on...