Isothiocyanates (ITCs) are naturally occurring molecules belonging to highly reactive organosulphur synthons, with the general structure R–N=C=S. The precursor molecule glucosinolate anions are hydrolyzed enzymatically (under the effect of myrosinase enzymes) or unenzymatically to produce nitriles or isothiocyanates depending upon conditions such as pH and temperature. Brassicaceae  Family is k...

Peppermint (Mentha piperita L.) is native to Mediterranean region which cultivated for food, pharmaceutical, and perfumery uses in all over the world. The aerial part of peppermint contains essential oil, phenolic and flavonoid compounds, fatty acids, vitamins, minerals, and salicylic acid. Menthol is the most important constituents of peppermint oil which synthesized and accumulated in glandul...

Introduction: Nausea and vomiting occur commonly during pregnancy cause inconvenience among pregnant women. Non-pharmacological therapy with warm ginger was used in this quantitative study to relieve nausea The aimed determine the effect of using on

Achillea santolina, Nepeta cataria and Salvia bucharica are mainly known to possess antispasmodic use in traditional medicine. The essential oils from these plants were screened for their possible pharmacological activity with possible mode of action explored. Volatile oil was extracted by steam distillation using standard procedure given in British Pharmacopoeia 2001. For pharmacological activ...

Rhus coriaria L. is known as Sumac. R. coriaria extracts are important in drug development with numerous pharmacological reputations in the South-Eastern Anatolia, Mediterranean area and Western Asia especially in Iran. Regarding the new multi-functional properties of R. coriaria and the related valuable ongoing reports, we were prompted to review the phytochemical an...

Personalized therapies are required for Fabry disease due to its large phenotypic spectrum and numerous different genotypes. In principle, missense mutations that do not affect the active site could be rescued with pharmacological chaperones. At present pharmacological chaperones for Fabry disease bind the active site and couple a stabilizing effect, which is required, to an inhibitory effect, ...

Arterial stiffness is an independent and powerful marker of all-cause mortality and cardiovascular morbidity and mortality. Pharmacological studies have shown that it is feasible to improve arterial stiffness or to slow its progression with a number of lifestyle modifications or pharmacological agents including antihypertensive, statins, nitrates, and others. Therapeutic improvement of arterial...