Two bacterial strains were isolated from pharmaceutical effluents discharged soil. The samples were identified as Klebsiella pneumonia and Pseudomonas aeruginosa the biological degradation was carried on two bacterial isolates separately added to pharmaceutical effluent water. After proper interval were analysed the physic chemical parameters such as pH, Turbidity, Chemical oxygen demand (COD),...

Drug counterfeiting has become a problem of immense magnitude worldwide which has aroused a significant level of attention among researchers, managers and policy makers. The counterfeit drug industry is estimated to be worth $200 billion a year [1] and has been defined as the “The crime of the 21st century” (ACG Report 2003), present in almost every industry with Asia appearing to be the single...

Ceftriaxone (CFTX) sodium is a third-generation, broad-spectrum cephalosporin that is resistant to betalactamases. An alternative bioassay for the assessment of the potency of this drug in pharmaceutical formulations has not been previously reported. Thus, this paper reports the development and full validation of a 3 x 3 agar diffusion bioassay using a cylinder-plate method to quantify CFTX sod...

A study was carried out to investigate compatibility of amlodipine besylate and olmesartan medoxomil with a variety of pharmaceutical excipients. Both drugs are antihypertensive agents that can be administered alone, in monotherapy, or in pharmaceutical association. The studies were performed using binary and ternary mixtures, and samples were stored for 3 and 6 months at 40°C under 75% relativ...

A new spectral library-based approach that is capable of screening a diverse set of finished drug products using only an active pharmaceutical ingredient spectral library is described in this paper. This approach obviates the need for a comprehensive drug product library, thereby streamlining the use of spectral library-based tests for anti-counterfeiting efforts, specifically to target finishe...

© 2012 Kapnissi-Christodoulou, licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Method Development by Use of Capillary Electrophoresis and Applications in P...

Introduction Total organic carbon (TOC) analysis provides a quick and efficient analytical process for cleaning validation in the pharmaceutical industry. When a single piece of equipment in a pharmaceutical manufacturing facility processes different active pharmaceutical ingredients (APIs), cross-contamination between products must be kept to an absolute minimum. Cleaning validation is the ove...