Further therapeutic options are urgently required for patients with biliary tract cancer (BTC), pancreatic ductal adenocarcinoma (PDAC), lung and bladder cancer, especially following failure of standard treatment. Mouse double minute 2 (MDM2) is amplified in ∼5–6% cases BTC, ∼1% PDAC, ∼4% adenocarcinomas ∼7% cancers. MDM2, an E3 ubiquitin ligase, endogenous negative regulator p53. Preclinical e...

Previously, algorithms for training conditional random fields were derived from the second-order Taylor expansion of the log-likelihood of the training data and the key issue is to approximate the Hessian matrix, which usually requires O(n) computations per iteration. In this paper, we show that efficient off-line and online algorithms for training conditional random fields (CRF) can also be de...

Persistent pulmonary hypertensin of the newborn (PPHN), a major clinical problem in the neonatal intensive care unit, can contribute significantly to morbidity and mortality in both term and preterm infants. Hypoxemic respiratory failure or PPHN can place newborns at risk for death, neurologic injury, and other morbidities. PPHN is categorized into parenchymal lung disease (meconium aspiration ...

S FOR INVITED SPEAKERS Decidualization In The Primate: Cellular And Molecular Changes Asgerally T. Fazleabas University of Illinois at Chicago Implantation in the baboon is similar to that described for the rhesus macaque. Specialized villi; known as anchoring villi, facilitate the attachment of the placenta to the uterine wall and provide the source of the migratory cell population that invade...