BACKGROUND Helicobacter pylori infection and subsequent gastric inflammation have been proposed as risk factors for the development of insulin resistance and cardiovascular disease. In this study we assessed the possible association of H. pylori bacterial load, and serum biomarker of gastric inflammation with cardiometabolic risk factors in diabetic patients. METHODS In this cross-sectional s...

INTRODUCTION: Costa Rica has among the highest mortality rates from gastric cancer in world, largely due to late detection. It is therefore important that economically and logistically sustainable screening implemented order detect risk of developing cancer. We have previously shown low pepsinogen (PG) values infection with Helicobacter pylori-CagA+ are associated atrophy Rican populations. OBJ...

Abstract Introduction Mazindol is the first partial orexin 2 receptor agonist and triple monoamine reuptake inhibitor in development for treatment of narcolepsy. Clinician Patient Global Impression (CGI PGI, respectively) cataplexy excessive daytime sleepiness were assessed as secondary endpoints phase (POLARIS, NLS-1021) multicenter study mazindol ER adult participants with narcolepsy type 1 (...

BACKGROUND Currently, non-invasive methods for screening atrophic gastritis and gastric cancer are lacking. The purpose of this study was to evaluate the value of serological parameters including serum pepsinogen I (PGI), pepsinogen II (PGII) and pepsinogen I: II ratio for the screening atrophic gastritis and gastric cancer. METHODS The study population consisted of 132 dyspeptic patients who...

Although histamine plays an essential role in inflammation, its influence on cyclooxygenases (COX) and prostanoid homeostasis is not well understood. In this study, we investigated the effects of histamine on the expression of COX-1 and COX-2 and determined their contribution to the production of PGE(2), prostacyclin (PGI(2)), and thromboxane A(2) in human coronary artery endothelial cells (HCA...

BACKGROUND The significance of cellular viability in human valve allografts for functional clinical longevity continues to be debated. Meaningful tests for this biological entity are therefore in demand to quantify the relative merits of graft origin and procurement techniques. The valve leaflet endothelium is recognized as a particularly sensitive target to noxes and its continued ability to p...

Abstract Background CaPaBLE tests the feasibility and acceptability of assessing quality life (QoL) using patient-, or caregiver-generated index (PGI/CaGI) methodology in patients with HGG their caregivers. Material Methods CaPaBLE, (https://www.isrctn.com/ISRCTN45555598), followed and/ caregivers up to 6 months. Standard measures for were EORTC QLQ-C30/BN20, CarGOQOL questionnaire. The QoL top...

Previous studies have shown that paragigantocellularis nucleus (PGI) neurons contain some neurotransmitters such as GABA, neuropeptides, monoamines, substance P, enkephalin and serotonin. It has been suggested that PGI is a main cholinergic source in the rat’s brain stem. There are few evidences on the presence and importance of cholinergic receptors on PGI neurons with regard to nociception. I...

An efficient synthesis of a highly potent and selective IP (PGI(2) receptor) agonist that is not structurally analogous to PGI(2) is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chlorophenyl)-oxazolidin-2-one prepared by a one-pot procedure with 4-piperidinol and selective O-alkylation of 1-(2-(4-chlorophenylamino)ethyl)piperidin-4...