lymphocyte leukemia. Semin Hematol. 2003;40:185-195. 3. Sivakumaran M, Richards SJ, Hunt K, et al. Patterns of CD16 and CD56 expression in persistent expansions of CD3 NKa lymphocytes are predictive for clonal T-cell receptor gene rearrangements. Br J Haematol. 1991;78:368377. 4. Lima M, Almeida J, Dos Anjos Teixeira M, et al. TCRalphabeta /CD4 large granular lymphocytosis: a new clonal T-cell ...

Currently, there is no standard treatment for patients with T-LGL. For asymptomatic T-LGL patients with an indolent course, a wait-and-see approach can be considered [11]. In our series, all 4 patients are alive and stable, with a slowly declining trend of platelets during the more than 3-year follow-up. T-LGL clonality could not be confirmed by a T-cell receptor gene rearrangement in our cases...

Abstract Chronic exposure to methamphetamine (METH) causes severe and persistent cognitive impairment. The present study aimed investigate the role of dynorphin/κ opioid receptor (KOR) system in development METH‐induced We found that mice showed significant impairment novel object recognition test (NOR) following daily injections METH (10 mg/kg) for seven consecutive days. Systemic blockade KOR...

Mutations associated with hematopoietic malignancies have been repeatedly identified in healthy individuals. For certain cases, such as the t(14;18) translocation and monoclonal B-cell lymphocytosis, no clear link between the presence of aberrant cells and the later development of cancer has been established. Intriguingly, longitudinal studies suggest that these abnormalities persist for long p...

Enzootic bovine leukosis (EBL) is a retroviral infection that causes persistent lymphocytosis and lymphosarcoma in cattle. The economic importance of infection by bovine leukemia virus (BLV) is due to several factors, including losses in exportation, treatment of secondary infection, and reduction in dairy production. To facilitate the development of a national test that is sensitive, simple, a...

A number of polymorphisms of the platelet glycoprotein (GP) Ib-V-IX and IIb/IIIa complexes have been described, and the Pl polymorphism of GP IIIa has been associated with coronary thrombosis. We determined the levels of b-thromboglobulin (b-TG) and platelet factor 4 (PF4) and the genotype distributions of Pl and a variable number tandem repeat (VNTR) polymorphism of GP 1b in subjects with acut...

Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic hematologic condition defined by the presence of a small (<5 x 10(9)/L) clonal B-cell population in the peripheral blood in the absence of lymph-node enlargement, cytopenias or autoimmune diseases. It is found in approximately 3-12% of normal persons depending on the accuracy of analytical techniques applied. According to the immunophenot...

CaAl2O4:Eu is a persistent luminescence (PL) material in the blue light region with potentially wide commercial applications. With the doping of Nd, the decay time can be elongated to more than 19 h. These excellent properties are believed to be in close relation with the electronic structures of the dopants, the defects, and the host material. In this work, we attempt to achieve a better under...