Pituitary adenylate cyclase activating polypeptide (PACAP) is a bioactive peptide with diverse effects in the nervous system. In addition to its more classic role as a neuromodulator, PACAP functions as a neurotrophic factor. Several neurotrophic factors have been shown to play an important role in the endogenous response following both cerebral ischemia and traumatic brain injury and to be eff...

Peripheral nerve regeneration occurs spontaneously after injury due to the permissive environment and activation of intrinsic growth capacity neurons. Injuries can be divided into three categories: neurapraxia, axonotmesis neurotmesis. Wallerian degeneration neurotmesis, affecting axon distal site damage. After this phase is complete, damaged neurons try rebuild fibers with axonal budding. Axon...

Phalanx fractures and interphalangeal joint dislocations commonly present to the emergency department. Although these orthopedic injuries are not complex, the four-point digital block used for anesthesia during the reduction can be painful. Additionally, cases requiring prolonged manipulation or consultation for adequate reduction may require repeat blockade. This case series reports four patie...

WELCH et al. add 112 well-documented adverse events from 380,680 patients to the third most commonly recognized cause of anesthesia litigation: Perioperative nerve injuries. This retrospective analysis from the University of Michigan collates three concurrent data sets (quality assurance, an internal closed-claims collection, and billing codes) to summarize the clinical experience with nerve in...

BACKGROUND Long-gap peripheral nerve defects arising from tumor, trauma, or birth-related injuries requiring nerve reconstruction are currently treated using nerve autografts and nerve allografts. Autografts are associated with limited supply and donor-site morbidity. Allografts require administration of transient immunosuppressants, which has substantial associated risks. To overcome these lim...

Digital nerve injuries are common; injuries of the common digital nerves are less frequent than those involving the proper digital nerves. Traditional techniques used to reconstruct peripheral nerves are: direct suture, autologous nerve grafts, autologous vein grafts, vascularised nerve graft and alloplastic nerve grafts. Autologous nerve grafts remain the most common conduits for segmental def...

BACKGROUND Sciatic nerve injuries often cause partial or total loss of motor, sensory and autonomic functions due to the axon discontinuity, degeneration, and eventual death which finally result in substantial functional loss and decreased quality of life. Nerve growth factor (NGF) plays a critical role in peripheral nerve regeneration. However, the lack of efficient NGF delivery approach limit...

Millions of people around the globe suffer peripheral nerve injuries caused by trauma and medical disorders. However, school curricula are profoundly deficient in education. This lack knowledge within healthcare profession may cause inadequate patient care. We developed Virtual Peripheral Nerve Academy (VPNA) as a reusable virtual learning environment to provide students with detailed education...

conclusions complete rupture of the facial nerve is challenging and the treatment is surgery, which requires careful planning. introduction facial paralysis is a devastating condition with profound functional, aesthetic and psychosocial consequences. tumors within or outside the skull, bell’s palsy and trauma are the most common causes of facial paralysis in adults. case presentation our patien...

Introduction In recent years, large earthquakes have occurred frequently all over the world.1-5 Earthquakes cause a large number of casualties with their catastrophic force. On May 12, 2008, an earthquake of 8.0 magnitude occurred in Wenchuan, Sichuan Province, in China. By May 25, 2008, 68,712 people had died, 374,640 were wounded, and 17,042 were reported missing. On January 12, 2010, a 7.3-m...