BACKGROUND In the clinical dentists and periodontal researchers' community, there is an obvious demand for a systems model capable of linking the clinical presentation of periodontitis to underlying molecular knowledge. A computer-readable representation of processes on disease development will give periodontal researchers opportunities to elucidate pathways and mechanisms of periodontitis. An ...

Periodontitis is a microbial-induced, chronic inflammatory disease that affects tissue and bone anchoring the teeth, and can ultimately lead to tooth loss. In addition, periodontitis may contribute to systemic diseases, such as cardiovascular disease (CVD), diabetes, rheumatoid arthritis (RA), and inflammatory bowel diseases. The pathogenesis of periodontitis is complex and involves bacterial p...

Aggressive periodontitis is a rare, severe and rapidly progressing periodontal disease. Early diagnosis is of utmost importance for establishing treatment in order to stop periodontal destruction and prevent tooth loss. The aim of this study is to describe the occurrence of aggressive periodontitis in patients at a Dental School in Brazil by means of a cross-sectional study. First, records from...

UNLABELLED An association between oral disease/periodontitis and rheumatoid arthritis (RA) has been considered since the early 1820s. The early treatment was tooth eradication. Epidemiological studies suggest that the prevalence of RA and periodontitis may be similar and about 5% of the population are aged 50 years or older. RA is considered as an autoimmune disease whereas periodontitis has an...

BACKGROUND A comprehensive knowledge about the mutual influence between diabetes and periodontitis is decisive for the successful treatment of both diseases. The present investigation aimed at assessing the diabetic and periodontal conditions and, in particular, the degree of knowledge about the relationship between diabetes and periodontitis. METHODS During a diabetes information program, 11...

BACKGROUND AND AIMS Periodontitis is an inflammatory disease, characterized by the loss of connective tissue and alveolar bone. There is an increasing evidence that periodontitis is associated with a number of chronic diseases. The aim of this study was to analyze the correlation between periodontitis and certain systemic diseases by identifying their risk factors in a population from North-Wes...

background and aims . periodontitis is a multifactorial disease. varieties of microbial and environmental, as well as genetic factors are reported to influence risk for periodontitis. the present study sought to test the putative involvement of il-10 and il-18 gene polymorphism in pre-disposition to periodontitis in patients had exposure to chemical agent as a risk factor for periodontitis deve...

BACKGROUND Interferon-γ (IFN-γ) is a key proinflammatory cytokine which plays a critical role in the pathogenesis and progression of periodontitis. The single nucleotide polymorphism of +874A/T in human IFN-γ gene can influence the secretion of IFN-γ and affect periodontitis susceptibility. However, the findings of published studies are inconsistent. Therefore, the goal of this meta-analysis is...

The recent article by Cani et al. (1) interests us very much. We have reported that obesity and periodontitis were associated for the first time in 1998 (2). Further study revealed that hepatic impairment was more strongly associated with periodontitis than obesity indexes (3). Our results showed that periodontitis increased with elevated serum levels of aspartate aminotransferase, alanine amin...

OBJECTIVE Epidemiological and recent clinical studies implicate periodontitis as an independent risk factor for cardiovascular disease. Previously, we demonstrated that rabbits with experimental periodontitis and cholesterol diet exhibit more aortic plaque compared with diet alone. We also showed that a proresolution mediator, Resolvin E1 (RvE1), reverses the experimental periodontitis. Here, w...