The objective of this study was to investigate the advantages and feasibility of periodontal tissue regeneration using platelet-rich fibrin (PRF) combined with rat periodontal ligament stem cells (PDLSCs) for the first time. We first determined the effect of PRF on rat PDLSCs in vitro. We next conducted an in vivo study, in which a tissue engineering technique was performed to repair periodonta...

Periodontal therapy has proven to be effective in the control and rehabilitation of periodontal diseases.1 Although initial therapy or the debrided phase is indicated for all types of periodontal diseases, it is not the only treatment that can or should be provided for patients suffering from moderate to advanced forms of periodontitis to achieve the appropriate goal of an environment that the ...

The efficacy of a non-steroidal anti-inflammatory agent, ibuprofen, was evaluated in pain control following periodontal surgery. This type of agent acts peripherally by inhibiting the release of prostaglandins and minimizing the local inflammatory response. Thus there may be an advantage in pre-treatment administration of the drug so as to delay or even prevent postoperative pain. The study was...

UNLABELLED Objective : Biomodification of the root surface plays a major role in periodontal wound healing. Root surface modification with bone morphogenetic protein (BMP) stimulates bone and cementum-like tissue formation; however, severe ankylosis is simultaneously observed. Bio-safe collagen hydrogel scaffolds may therefore be useful for supplying periodontal ligament cells and preventing an...

OBJECTIVE To explore the relationship between cone beam computed tomography (CBCT) measurements and direct measurements during the surgery to correct intrabony defects. METHODS Forty-four patients with 44 intrabony defects who finished initial periodontal therapy and were considered for periodontal surgery were recruited. Digital periapical radiography and CBCT was performed before the surger...

The purpose of this study was to evaluate the clinical efficacy of initial periodontal therapy in gingival pregnancy tumors. Thirty-nine patients diagnosed with gingival tumors of pregnancy between 2007 and 2015 were enrolled in this study. The patients received initial periodontal therapy, then supportive periodontal therapies at 3- to 6-month intervals. The patients underwent follow up for 6 ...

In periodontal research, animal studies are complementary to in vitro experiments prior testing new treatments. Animal models should make possible the validation of hypotheses and prove safety efficacy regenerating approaches using biomaterials, growth factors or stem cells. Rats, hamsters, rabbits, ferrets, dogs, primates just a few many kinds animals that have been utilised as for human illne...

OBJECTIVE Collagen hydrogel scaffold exhibits bio-safe properties and facilitates periodontal wound healing. However, regenerated tissue volume is insufficient. Fibroblast growth factor-2 (FGF2) up-regulates cell behaviors and subsequent wound healing. We evaluated whether periodontal wound healing is promoted by application of collagen hydrogel scaffold in combination with FGF2 in furcation de...

OBJECTIVES This double-blind randomized placebo-controlled clinical trial evaluated the ability of a desensitizing agent and a self-etch adhesive on cervical dentin sensitivity (CDS) after periodontal surgery. MATERIALS AND METHODS Ninety hypersensitive teeth of 13 subjects were included in the study. After periodontal surgery, the teeth of each posterior sextant treated with one of the follo...

Aesthetic concerns play a major role in the treatment planning of dental care and in every periodontal practice. Gingival recessions are one of the prevalent problems that require clinicians’ attention because of the patient’s aesthetic demands and the possible health complications, such as dentin hypersensitivity and root caries. The cosmetic expectations of our patients and their dental healt...