Human periodontal ligament (PDL) cells obtained from extracted teeth are a potential cell source for tissue engineering. We previously reported that poly(2-methoxyethyl acrylate) (PMEA) is highly biocompatible with human blood cells. In this study, we investigated the adhesion, morphology, and proliferation of PDL cells on PMEA and other types of polymers to design an appropriate scaffold for t...

Purpose The aim of this study was to evaluate the relationship between initial probing depth (IPD) and changes in clinical parameters following non-surgical periodontal treatment (NPT) in chronic periodontitis patients. Subjects and Methods A total of 1672 periodontal pockets having 3mm≤IPD≤9mm of depth in 15 chronic periodontitis patients were included. NPT consisting of oral hygiene instruc...

BACKGROUND Human periodontal ligament (PDL) cells underwent apoptosis after mechanical stretch loading. However, the exact signalling pathway remains unknown. This study aimed to elucidate how the apoptotic caspases functioned in the cyclic stretch-induced apoptosis in human PDL cells. MATERIALS AND METHODS In the present study, 20% cyclic stretch was selected to load the cells for 6 or 24 h....

A review of the current scientific literature was undertaken to evaluate the efficacy of minimally invasive periodontal regenerative surgery in the treatment of periodontal defects. The impact on clinical outcomes, surgical chair-time, side effects and patient morbidity were evaluated. An electronic search of PUBMED database from January 1987 to December 2011 was undertaken on dental journals u...

During orthodontic treatment, periodontium remodeling of periodontitis patients under mechanical force was abnormal. We have previously confirmed the function impairment of periodontal ligament stem cells (PDLSCs) in the periodontitis microenvironment which might be involved in this pathological process. However, the response of PDLSCs in periodontitis microenvironment to mechanical force remai...

In vitro and animal studies suggest a possible role for the tetracycline class of drugs in the inhibition of non-enzymatic protein glycation. We conducted a 3-month, randomized placebo-controlled pilot clinical trial of conventional sub-gingival debridement (periodontal therapy), combined with either a three month regimen of sub-antimicrobial-dose doxycycline (SDD), a two week regimen of antimi...

Objective:The aim of this parallel controlled randomized clinical trial was to evaluate the clinical efficacy of ultrasonic subgingival debridement in combination with Er:YAG laser as compared to full mouth ultrasonic subgingival debridement alone, after one year, in patients with initial to moderate chronic periodontitis. Material & Methods: 40 patients diagnosed with mild to moderate periodon...

Periodontal ligament-associated protein-1 (PLAP-1/asporin) is a special marker in periodontal ligament tissue. It is an important regulator of osteogenic differentiation of periodontal ligament cells (PDLCs). This marker is also a prerequisite for periodontal ligament development and mineralization in maintaining homeostasis of the periodontium. H...

vulvar necrotizing fascitis is an uncommon infectious disorder. since the first reported cases almost 100 years, ago, necrotizing fasciitis continues to present a diagnostic and therapeutic challenge. what usually begins as a subtle infection can become life-threatening. we report two cases of vulvar necrotizing fasciitis, one after posterior colporrhaphy in a woman with four risk factors and t...

introduction: the use of lasers for treatment has become a common phenomenon in the medical field. currently, numerous laser systems are available for dental use. the use of lasers for periodontal treatment becomes more complicated because the periodontium consists of both hard and soft tissues. methods: related articles were gathered and selected carefully and reviewed. among the many lasers a...