BACKGROUND Ki-67 which is a non-histone nuclear protein which is expressed in proliferating cells, during all the active phases of the cell cycle. Increased Ki-67 expression has been seen in several inflammatory and malignant conditions like diabetes, rheumatoid arthritis, atherosclerosis, pancreatitis and squamous cell carcinoma. AIM The aim of the present study is to analyze the expression ...

In the past decade, periodontal disease has been recognized as not merely a local infectious disease, but as chronic, subclinical, inflammatory disease for the host. Diabetic subjects appear to respond to bacterial challenge in an exaggerated manner as compared with non-diabetic subjects through several possible mechanisms, and develop more severe forms of inflammatory periodontal disease. Seve...

OBJECTIVE The purpose of the proposed study was to develop an identification unit for classifying periodontal diseases using support vector machine (SVM), decision tree (DT), and artificial neural networks (ANNs). MATERIALS AND METHODS A total of 150 patients was divided into two groups such as training (100) and testing (50). The codes created for risk factors, periodontal data, and radiogra...

OBJECTIVE Although many studies reported more severe periodontal disease and the existing proinflammatory conditions in patients with diabetes but only few have examined the effect of type 2 diabetes mellitus (DM) on salivary matrix metalloproteinase-8 (MMP-8) level and other periodontal parameters. This study aims to evaluate the effect of type 2 DM on salivary MMP-8 levels and periodontal par...

BACKGROUND/AIMS IL-4 is a multifunctional cytokine that is related with the pathological conditions of periodontal disease. However, it is uncertain whether IL-4 could control T cells migration in periodontal lesions. The aim of this study was to examine the effects of IL-4 on CCL11, which is a Th2-type chemokine, and CCL20, which is related with Th17 cells migration, productions from human per...

BACKGROUND The association between diabetes and inflammatory periodontal diseases has been studied extensively for more than 50 years. The author reviews the bidirectional relationships between diabetes and periodontal diseases. CONCLUSIONS A large evidence base suggests that diabetes is associated with an increased prevalence, extent and severity of gingivitis and periodontitis. Furthermore,...