A major function of xenobiotic and endobiotic transporters is to move a wide range of organic substances across cell membranes. Sertoli cells play an important role in protecting developing germ cells by forming a physiological barrier, limiting exposure to potentially toxic substrates, or conversely, facilitating uptake of xenobiotics within the testis. The aim of this study was to quantitativ...

Transporters influence the disposition of chemicals within the body by participating in absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) comprise a variety of proteins, including organic cation transporters (OCT) 1 to 3, organic cation/carnitine transporters (OCTN) 1 to 3, organic anion transporters (OAT) 1 to 7, various organic anion transporting polyp...

Acylase I (aminoacylase; N-acylamino-acid amidohydrolase, EC 3.5.1.14, from porcine kidney and the fungus Aspergi l lus) is a broadly appl icable nzymatic atalyst for the kinetic resolut ion of unnatural and rarely occurring a-amino acids. I ts enantioselectivi ty for the hydrolysis of N-acyl L-a-amino acids is nearly absolute, yet i t accepts ubstrates having a wide range of structure and func...

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The regulation of gastric acid secretion is complex and involves endocrine, paracrine, and neurocrine mechanisms. Among these, the interconnecting cross-talk between different gut peptides is an important part in the control of acid secretion. The aims of this thesis were (1) to develop a new method of measuring intragastric pH for prolonged periods of time, and (2) apply developed and in-use m...

-1. Testes of Heliothis virescens synthesized ecdystel the optimum calcium titer for testis sheaths stimulated to synl the optimum for testes stimulated in vitro with the peptide 2. Verapamil at concentrations lower than 10 -3 M induced more efficient synthesis when calcium influx was inhibited. 3. Hemolymph of H. virescens was 7 mM in calcium, wh calcium. I N T R O D U C T I O N in oil Gelm dc...

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Two small, multicopy, expression plasmids were constructed that permit convenient Insert ion of trpR. the structural gene for the t r £ repressor of Escherichja c o l l . with I t s natural rlbosome binding s i te or adjacent to the Mbosome bindTn? s i te for the t r £ leader peptide. In these plasmids trpR 1s positioned between the strong regulated ta£ promoter and the rpoC transcr ipt ion ter...