We have taken advantage of a newly described Drosophila model to gain insights into the potential mechanism of antiepileptic drugs (AEDs), a group of drugs that are widely used in the treatment of several neurological and psychiatric conditions besides epilepsy. In the recently described Drosophila model that is inspired by pentylenetetrazole (PTZ) induced kindling epileptogenesis in rodents, c...

Numerous studies have demonstrated the antioxidant effects of grape seed proanthocyanidin extract (GSPE). The generation of free radicals and the ensuing apoptosis may contribute to the pathogenesis of epilepsy; therefore, in the present study, we examined the effects of GSPE on cognitive impairment and neuronal damage induced by chronic seizures in rats. Seizures were induced by a daily intrap...

traumatic brain injury (tbi) is an important clinical problem in the worldwide and especially due to breaking driving rules in iran, but undesirable consequences of trauma can persist for the rest of patient’s life. we investigated the effect of a novel weight drop model of tbi on incidence of seizure 2 weeks after tbi. in this regard, 21 male wistar rat weighted 250-300 gr randomly were divide...

Objective: Previously, analgesic, hypnotic, and anticonvulsant effects have been suggested for Rosa damascena (R. damascena). In the present study, possible anti-seizure and neuro-protective effects of hydro-alcoholic extract of R. damascena has been investigated after inducing seizures in rats by pentylenetetrazole (PTZ). Materials and Methods: The rats were divided to five groups: (1) Control...

Considering the prevalence of epilepsy and problems associated with currently available antiepileptic drugs like side effects, resistance, safety issue high cost, herbal medicine fewer complications could be very appropriate alternative. Therefore in present study, we have examined properties ethanolic extract leaves mice using maximal electroshock seizers (MES)test, Pentylenetetrazole (PTZ), i...

OBJECTIVES Phthalimide-based derivatives have anticonvulsant activity like as phenytoin by inhibition of sodium channel. In our previously research we mentioned about some phthalimide derivatives as potent anticonvulsant agents. MATERIALS AND METHODS Fourteen analogs of 2-substituted phthalimide pharmacophore were synthesized and then were evaluated for the anticonvulsant activities in pentyl...

The stem barks of Calotropis gigantea Linn. (Asclepiadaceae) a widely growing plant has been reported to possess number of medicinal properties. The purpose of the present study was to evaluate scientifically the anti-convulsant effect of barks of the plant used traditionally in Indian system of medicine, using MES and PTZ induced seizure models. The effect of different extracts of stem barks o...

The aim of the current study was to elucidate whether the response of the adult rat brain to thyroid hormones is affected by the intensity of neuronal activity. For this purpose, the kinetic characteristics of nuclear T3 binding, the relative expression of thyroid hormone receptor (TR) isoforms and the synaptosomal content of thyroid hormones in adult rat brain were examined after administratio...

objective: previously, analgesic, hypnotic, and anticonvulsant effects have been suggested for rosa damascena (r. damascena). in the present study, possible anti-seizure and neuro-protective effects of hydro-alcoholic extract of r. damascena has been investigated after inducing seizures in rats by pentylenetetrazole (ptz). materials and methods: the rats were divided to five groups: (1) control...

Objective: Nitric oxide (NO) plays an important role both as a consequence and as a cause of epileptic seizures.Regarding the central nervous system depressant effects of Achillea wilhelmsii (A. wilhelmsii), as well the effects of the plant on NO, this study was aimed to elucidatethe possible role for nitric oxide on the effects of hydroalcoholic extract of A. wilhelmsii on pentylenetetrazole (...