Microinjections of D,L-homocysteic acid (DLH) were used to test the hypothesis that neuronal activation within the Botzinger complex area can modify the spatiotemporal characteristics of the cough reflex in 17 spontaneously breathing pentobarbitone anesthetized cats. DLH (50 mM, 1.25-1.75 nmol, 9 cats) reduced the number (P<0.01) of coughs and expiratory amplitude of abdominal electromyographic...

We have compared the effects of isoflurane, propofol, ketamine and pentobarbital on parasympathetic reflex vasodilatation to investigate their involvement in GABA-mediated synaptic inhibition, enhancement of which is thought to underlie the action of many anaesthetic agents. In cats anaesthetized with urethane-alpha-chloralose, parasympathetic reflex vasodilation in the ipsilateral lower lip wa...

Erythrophleum ivorense is used traditionally for many ailments such as convulsion, swellings, pain and emesis. Therefore, this study aimed to investigate the anticonvulsant and sedative activities of extracts of Erythrophleum ivorense stem bark in mice. Anticonvulsant effect of the extracts was assessed using picrotoxin, pentylenetetrazole and strychnine-induced convulsion and sedative effect w...

Effect of a triterpene isolated from the acetone soluble part of petroleum ether extract of R. cordifolia was studied on convulsions induced by maximum electro shock (MES), electrical kindling and various chemoconvulsants in rats and mice. The effect of triterpene was also investigated on behavior and gamma-aminobutyric acid (GABA) and serotonin (5-HT) content in mouse brain. Triterpene inhibit...

This compound (Ro-4-1778) 'which is chemically (l-(p-chlorophenethyl)6-7dimethoxy-2-methyl 1, 2, 3, 4 tetrahydro isoquinoIine) was synthesised by Brossi et aI. (1960). Its analgesic activity in rats has been reported by Gupta and Gaitonde (1964). An observation was made that the drug produced analgesia in a dose range 10-50 mg/Kg, but in a few animals receiving a dose of 50 mg/Kg., there wasan ...

IN a previous publication, the author reported that an increased sensitivity to pain followed the use of small doses of thiopentone and pentobarbitone (Dundee, 1960), thus confirming the findings of Clutton-Brock (1960). It was suggested that this anti-analgesic action of thiopentone was due to low concentrations of the drug in the brain and the phenomenon was also demonstrated in the postopera...