Intramolecular cycloadditions of photogenerated azaxylylenes provide access to unprecedented polyheterocyclic scaffolds, suitable for subsequent postphotochemical modifications to further grow molecular complexity. Here we explore approaches to rapid "assembly" of novel photoprecursors with nitrogen/oxygen-rich tethers capable of producing potential pharmacophores and also compatible with subse...

the center (periphery) of a graph is the set of vertices with minimum (maximum)eccentricity. in this paper, the structure of centers and peripheries of some classes ofcomposite graphs are determined. the relations between eccentricity, radius and diameterof such composite graphs are also investigated. as an application we determinethe center and periphery of some chemical graphs such as nanotor...

we study the set of all determinants of adjacency matrices of graphs with a given number of vertices. using brendan mckay's data base of small graphs, determinants of graphs with at most $9$ vertices are computed so that the number of non-isomorphic graphs with given vertices whose determinants are all equal to a number is exhibited in a table. using an idea of m. newman, it is proved that if $...

Abstract Interactions between pentacyclic triterpenes isolated from white birch (Betula pendula Roth.) bark samples Northeast Bulgaria and bovine serum albumin or human were investigated using fluorescence techniques. The experimental results show the formation of complexes with albumins. Quenching intrinsic albumins was monitored by emission spectra varied quencher concentration solutions. By ...

mean labelings are a type of additive vertex labeling. this labeling assigns non-negative integers to the vertices of a graph in such a way that all edge-weights are different, where the weight of an edge is defined as the mean of the end-vertex labels rounded up to the nearest integer. in this paper we focus on mean labelings of some graphs that are the result of the corona operation. in parti...

Lycoposerramine A (1) is a pentacyclic alkaloid isolated in 2001 by Takayama and co-workers. A concise synthesis of a model compound 8 for the tetracyclic core of this natural product is described. Key steps include the desymmetrising free-radical cyclisation of compound 7 to give compound 18 and spirocyclisation of compound 26 to give compound 8. Earlier approaches using a novel high-yielding ...

Feature article: a panel of Lyme experts present bold new data demonstrating the therapeutic effects of Pentacyclic Alkaloid Chemotype U n c a r i a tomentosa (TOA-free Cat’s Claw) to be effective in the treatment of chronic Lyme disease. See page 3 Q & A section with Lyme experts about testing methods, natural therapies, neurotoxins associated with Lyme, and dealing with treatment-related toxi...

A dichloromethane extract of the soft coral Rhytisma fulvum fulvum collected in Madagascar afforded a novel compound possessing an unprecedented pentacyclic skeleton, bisdioxycalamenene (1), as well as seven known sesquiterpenes. The structures of the compounds were elucidated using 1D and 2D NMR techniques, as well as high-resolution mass spectrometry. The absolute configuration of 1 was deter...

Samarium diiodide (SmI2) smoothly promotes the cyclizations of suitably substituted carbonyl compounds with styrene subunits leading to benzannulated cyclooctenes. The intramolecular samarium ketyl addition to arene or hetarene moieties enables a new, efficient, and highly stereoselective entry to dearomatized products such as hexahydronaphthalenes, steroid-like tetraor pentacyclic compounds, o...

Chemical investigation of the lipophilic fraction of Hyrtios erectus, a Red Sea sponge, yielded a new pentacyclic nitrogen-containing scalarane; 24-methoxypetrosaspongia C (1), together with the previously reported scalaranes sesterstatin 3 (2), 12-deacetyl-12-epi-scalaradial (3) and 12-deacetyl-12,18-di-epi-scalaradial (4). The compounds were identified using HRESIMS, 1D and 2D NMR experiments...