The in vitro anti-inflammatory effects of seven known lignans and one dihydrochalcone isolated from the leaves of two Lauraceae species (Pleurothyrium cinereum and Ocotea macrophylla), were evaluated through the inhibition of COX-1, COX-2, 5-LOX and the aggregation of rabbit platelets induced by PAF, AA and ADP. (+)-de-4"-O-methylmagnolin 4 was found to be a potent COX-2/5-LOX dual inhibitor an...

Fig 6, " Boron concentration ([B f ], μg g-1 DW) and boron content (B f , μg) in (A) soluble in water, (B) soluble in organic solvents and (C) insoluble fractions measured in roots and leaves of Citrus macrophylla seedlings grown for 25 days in B-normal (50 μM, Ct) and B-toxic (400 μM, +B) nutrient solutions, " appears incorrectly. Please see the corrected Fig 6 here. Copyright: © 2015 Martínez...

Most of the medicinal agents are originated from nature and considered as a rich source for producing drugs including modern drugs. Swietenia machrophylla is one of the most important plant of the family, Meliaceae. It is planted widely in Southern Asia and in the Pacific region. This review provides information on its traditional uses, phytochemical and medicinal values. The plant extracts and...

Background Loco-regional relapses (LRRs) from rectal cancer still represent a major issue in colo-rectal surgery. With the introduction of Total Mesorectal Excision (TME), LRR incidence after curative resection for rectal cancer dramatically decreased from 20–40% of cases to 2–12%. Several factors are involved in predicting LRRs, the most important of these being Dukes stage. When no treatment ...

On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D ((1)H-(1)H COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compou...

The title compound, a natural b,d-seco-limonoid, C(27)H(34)O(8)·H(2)O, and known as Swietenolide monohydrate, has been isolated from S. macrophylla King. In the molecular structure, the four fused six-membered rings adopt twist-boat (ring A), approximate chair (ring B), envelope (ring C) and half-chair (ring D) conformations. The attached furan ring is essentially planar. O-H⋯O hydrogen bonds a...

Endophytic bacteria from three arboreal species native to the Amazon (Carapa guianenses, Ceiba pentandra, and Swietenia macrophylla), were isolated and identified, through partial sequencing of the 16S rRNA encoding gene. From these, 16 isolates were obtained, although, when compared to sequences deposited in GenBank, only seven had produced identifiable fragments. Bacillus, Pantoea and two non...