We report a case of Stomatococcus mucilaginosus endocarditis in which the isolate was relatively resistant to penicillins and cephalothin. The patient was treated successfully with vancomycin and valve replacement.

A novel beta-lactamase with a broad spectrum of activity against penicillins and cephalosporins has been detected in a strain of Klebsiella aerogenes. Its synthesis is mediated by an R-plasmid of molecular weight 64 x 10(6).

THE report of the red dye, prontosil, as a chemotherapeutic agent (Domagk, 1935) was followed by the demonstration that its activity depended upon sulphanilamide. Analogues with a wider antibacterial range soon became available. A decade getting to know the sulphonamides was followed by another learning to use penicillin. The nineteen-fifties witnessed the introduction of broad-spectrum antibio...

The in vitro activity of nafcillin, oxacillin, and methicillin alone and in combination with gentamicin and tobramycin against 30 strains of enterococci was investigated. The penicillinase-resistant penicillins were less active than penicillin and ampicillin against the enterococci. Nafcillin was more active than oxacillin and methicillin. Sixty-six percent of strains were inhibited by nafcilli...

Although there are a large number of species of fungi, only a relative few have been found to produce antibiotics, and only seven antibiotics are produced commercially. The 1970 Information Bulletin, No. 8 (3) of the International Center of Information on Antibiotics lists 338 species of fungi that produce antibiotics. According to 1967 (11) and 1970 (13) lists assembled by Perlman, the followi...

Introduction Cephalosporins are beta-lactam antimicrobials that share mechanisms of action and a similar structure with penicillins (Figure). Penicillins and cephalosporins have the same four-member “core” beta-lactam ring, but cephalosporins have an additional atom in the side ring. Modified side chains on either ring alter antimicrobial activity, resistance to beta-lactamases, or pharmacokine...

Elucidation and quantitative determination of some of commonly used penicillins (ampicillin, penicillin G and carbenicillin) in the presence of their main degradation product (penicilloic acid) were developed. Forced acidic and basic degradation processes were applied at different time intervals. The formed degradation products were elucidated and quantified using surface enhanced Raman spectro...