Transdermal delivery is an attractive option for drug delivery. Nevertheless, the skin is a tough barrier and only a limited number of drugs can be delivered through it. The most difficult to deliver are hydrophilic drugs. The stinging mechanism of the cnidarians is a sophisticated injection system consisting of microcapsular nematocysts, which utilize built-in high osmotic pressures to inject ...

Recent clinical studies on human skin indicated that in vivo multi-harmonic generation microscopy (HGM) can achieve sub-micron resolution for histopathological analysis with a high penetration depth and leave no energy or photodamages in the interacted tissues. It is thus highly desired to apply HGM for in vivo mucosa histopathological diagnosis. In this paper, the first in vivo optical virtual...

We have investigated the mechanism through which the penetration enhancer oleic acid acts on stratum corneum (SC) model membranes (bovine brain ceramide:cholesterol:palmitic acid, 1:1:1 molar ratio). We used solid state deuterium nuclear magnetic resonance to monitor such multilamellar SC dispersions containing either cholesterol-d(6), palmitic acid-d(31), or oleic acid-d(2) as a function of bo...

The first signs of mobile commerce hype are here. Extremely rapid penetration and growth processes are predicted on the basis of some quick descriptions of mobile technology. The roots of these predictions are often found in markets with a low penetration rate of mobile technology. Nevertheless, it should be clear that without real substance in m-commerce products and services the investments i...

This paper gives an overview on the potentials of numerical simulations for understanding dynamics in laser material processing. After a short introduction into the model, simulation results on several processes like laser beam deep penetration welding, drilling or cutting are presented. Furthermore simulation results are compared with experimentally obtained data.

This paper analyzes the impact on mobile telephony diffusion patterns of the two predominant payment regimes, calling party pays (CPP) and receiving party pays (RPP), for mobile termination services. By applying instrumental variable techniques to panel data we account for a possible interdependency of penetration rates and regulatory interventions. For this purpose we use data on political and...

It is important for search and pay-per-click engines to penetration test their click fraud detection systems, in order to find potential vulnerabilities and correct them before fraudsters can exploit them. In this paper, we describe: (1) some goals and desirable qualities of a click fraud penetration testing system, based on our experience, and (2) our experiences with the challenges of buildin...

Soil stiffness constants govern the soil sinkage and the pressure-sinkage behaviour of the soil under load. To determine soil stiffness constants in Upadhyaya model under field conditions, a field reflecting general character of an agricultural soil was selected and multiplate penetration tests were conducted. The soil stiffness constants in Upadhyaya model were determined from five sets of soi...

In this study, spontaneous vesicle formation from the sodium salt of acidic sophorolipid (SLNa) was observed, and its potential application as a skin penetration enhancer for triterpene glycosides extracted from the fruits of Siraitia grosvenorii Swingle was then investigated. Dynamic light scattering (DLS) measurements of the SLNa assemblies prepared by the gentle mixing of SLNa with water (1%...

The objective of the study was to develop a suitable trans-dermal delivery system for propranolol hydrochloride (PPL) via employing chitosan as a film former. Drug concentration uniformity, thickness, moisture uptake capacity and skin bioadhesion of the films were characterized. The effects of chitosan and PPL concentration and different penetration enhancers on the release and permeation profi...