The development of shorthand handwriting recognition for pen-centric interfaces can provide the critical infrastructure for natural pen-centric interactions to enhance many pen-centric learning applications. The technical innovations include chatroom and special-symbol shorthand as well as appropriate online handwriting recognition strategies for small form-factor devices. Famous writers throug...

In a previous study, we developed an interface using semisynchronous speech and pen input. In this interface, a user speaks while writing, and the pen input complements the speech, enabling a higher recognition performance than with speech alone. When a user inputs speech and pen, there is a time lag between the two modes, and the lag differs among users. We propose a method for adapting to the...

Administration of insulin via a pen device may be advantageous over a vial and syringe system. Hofman and colleagues introduce a new insulin pen needle, the NovoTwist, to simplify injections to a small group of children and adolescents. Their overall preferences and evaluation of the handling of the needle are reported in the study. This new needle has the potential to ease administration of in...

The scope of this work is the combination of the organic semiconductor pentacene (PEN) with different conjugated organic molecules to form application relevant heterostructures in vacuum sublimed films. Following a multi-technique approach – comprising x-ray diffraction, vibrational spectroscopy, atomic force microscopy and photoelectron spectroscopy – PEN heterostructures with (i) fullerene (C...

Quantified transmission parameters of Foot-and-Mouth Disease Virus (FMDV) are needed for epidemic models used for control and surveillance. In this study, we quantified the within- and between-pen transmission of FMDV in groups of pigs by estimating the daily transmission rate beta, i.e. the number of secondary infections caused by one infectious pig during one day, using an SIR (susceptible-in...

Recent advances in interactive pen-aware systems, pattern recognition technologies and human-computer interaction have provided new opportunities for pen-based communication between human users and intelligent computer systems. Using interactive maps, users can annotate pictorial or cartographic information by means of pen gestures and handwriting. Interactive maps may provide an efficient mean...

Gamma-secretase-mediated Notch3 signaling is involved in smooth muscle cell (SMC) hyper-activity and proliferation leading to pulmonary arterial hypertension (PAH). In addition, Propylthiouracil (PTU), beyond its anti-thyroid action, has suppressive effects on atherosclerosis and PAH. Here, we investigated the possible involvement of gamma-secretase-mediated Notch3 signaling in PTU-inhibited PA...

Penicillium notatum is a well-known indoor aeroallergen and is frequently included in skin test panels for allergic diagnosis. On two-dimensional immunoblotting using patients' sera containing IgE and monoclonal antibody D7B8 specific for Pen c 1 of P. citrinum, two allergens with a molecular mass of 33 kDa but different isoelectric points were identified. A novel cDNA coding for Pen n 13 was c...

BACKGROUND For surgical suturing, a Webster needle holder uses wrist supinating with supinator and extrinsic muscles, whereas a pen needle holder uses finger twisting with intrinsic and extrinsic muscles. Because the latter is better suited to microsurgery, which requires fine suturing with less forearm muscle movement, we have recently adopted an enlarged pen needle holder scaled from a micro ...

BACKGROUND A shisha-pen is an electronic cigarette variant that is advertised to mimic the taste of a water pipe, or shisha. The aim of this study was to assess the potential harmful health effects caused by inhaling the vapor of a nicotine-free shisha-pen. METHODS Gas chromatography analysis was performed to determine the major components in shisha-pen vapor. Risk assessment was performed us...