نتایج جستجو برای: pemphigus foliaceus
تعداد نتایج: 3303 فیلتر نتایج به سال:
ALTHOUGH there are numerous reports of individual cases, only a few papers deal with general aspects of the clinical picture of generalized vaccinia (Tedder, I936; Clark, Seiler, Joe, Gammie, Tait and Jack, I944; Fries, Borne and Barnes, I948). During two outbreaks of generalized vaccinia occurring, after two mass vaccinations, in a hospital for patients with pemphigus foliaceus, some clinical ...
CYP: cytochrome P INTRODUCTION Pemphigus foliaceus is a rare autoimmune bullous dermatosis that can be induced by drugs, with variable duration lasting between several weeks and months. Erythematous scaly patches develop on the scalp, face, neck or chest. The use of oral or topical herbal supplements to improve health has increased in the last decades. These preparations may trigger multiple ad...
BACKGROUND Rituximab, a monoclonal anti-CD20 antibody, has been used with encouraging results in pemphigus. We describe herein refractory cases of pemphigus vulgaris (n = 23) and pemphigus foliaceus (n = 1) treated with rituximab in addition to steroids and immunosuppressants. AIMS To assess the response to treatment, the duration of clinical remission, serology of the response and adverse ef...
Pemphigus foliaceus (PF) is characterized by acantholysis determined by IgG4 binding to desmoglein I, a 160-kDa desmosomal glycoprotein. To investigate the immunopathological aspects of Brazilian PF, we determined levels of serum cytokines in patients with PF. Twenty-five patients with PF and a control group consisting of 10 healthy individuals were studied. Serum IL-2, IL-4, IL-5, IL-10, IL-12...
Binding of anti-cell surface pemphigus autoantibodies to cultured human epidermal cells stimulates synthesis and secretion of plasminogen activator (PA). Increases in PA activity were detected within 6 h of the addition of IgG and stimulation was dependent upon IgG concentration. Stimulation of PA activity was inhibited by cycloheximide, which indicates that synthesis of protein was necessary. ...
IL-23/IL-17 axis has been identified as major factor involved in the pathogenesis of several autoimmune diseases; yet its pathogenetic role in pemphigus vulgaris (PV) remains controversial. The aim of this research was to investigate the potential role of IL-23/IL-17 axis in the immunopathogenesis of PV, and correlation between IL-23+ cells and IL-17+ cells was also evaluated. For this purpose,...
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