An Bras Dermatol. 2017;92(4):584-95. Dear editor, Pemphigus is an autoimmune bullous disease that can affect the skin and mucous membranes, mediated by autoantibodies against desmosomal desmogleins, the main adhesion structures Marina Zoega Hayashida1 Jhonatan Rafael Siqueira Pinheiro1 Milvia Maria Simões e Silva Enokihara2 Mônica Ribeiro de Azevedo Vasconcellos1 t Biologic therapy-induced pemp...

COOPER (1858) first described the ocular manifestations of pemphigus. von Kries (1878), working in von Graefe's clinic, described "essential shrinkage of the conjunctiva", and von Graefe (1879) identified the terminal state of pemphigus with essential shrinkage of the conjunctiva. By 1892, when Duane translated Fuchs's textbook into English, the diagnosis of pemphigus conjunctivae was establish...

Yoshimura et al. set out to characterize the clinical and immuno logical profiles of patients with drug-induced pemphigus. They studied 17 Japanese patients with druginduced pemphigus diagnosed between 1997 and 2012. They recorded clinical and histopathological manifestations, responsible drugs, immunofluorescence findings, enzymelinked immunosorbent assay (ELISA) and immunoblotting (IB) result...

Background: Pemphigus vulgaris, a chronic mucocutaneous disease, is the most prevalent type of pemphigus which manifests with development of bullae and erosions on skin and mucosal membranes. Objectives: To investigate the potential role of IL-23 in pemphigus vulgaris. Methods: In this study, 30 patients with pemphigus vulgaris and 30 healthy individuals were selected according to inclusion and...

Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the lupus band test. In the present paper, we determined whether the autoantibodies associate...

The pemphigus group comprises the autoimmune intraepidermal blistering diseases classically divided into two major types: pemphigus vulgaris and pemphigus foliaceous. Pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus are rarer forms that present some clinical, histological and immunopathological characteristics that are different from the classical types. Th...

BACKGROUND Pemphigus is an acquired autoimmune intraepidermal blistering disease that is divided into 2 major subtypes: pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Patients with pemphigus have circulating anti-desmoglein (Dsg)1 and/or anti-Dsg3 IgG autoantibodies. Recently, a novel commercial enzyme-linked immunosorbent assay (ELISA) against Dsg1 and Dsg3 has been established and foun...

OBJECTIVE Autoimmune bullous diseases are heterogeneous diseases and the differentiation between the various bullous disease is important for treatment and prognosis. Direct immunofluorescence microscopy is still the gold standard in differentiating these diseases. Our aim was to determine the diagnostic accordance between clinical and histopathological/direct immunofluorescence diagnosis of pa...

Pemphigus is a severe, potentially fatal bullous skin disease, caused by desmoglein autoantibody production and immune-mediated regulation of T-cells subsets. Conventional therapy including systemic corticosteroids with or without other immunosupressants causes numerous adverse effects and becomes inefficient in refractory patients. In this work, the authors showed a modern view on the pathogen...