نتایج جستجو برای: pegylation

تعداد نتایج: 824  

Journal: :The Journal of pharmacology and experimental therapeutics 2014
George Mattheolabakis Chi C Wong Yu Sun Carol A Amella Robert Richards Panayiotis P Constantinides Basil Rigas

Esterase hydrolysis of drugs can accelerate their elimination, thereby limiting their efficacy. Polyethylene glycol (PEG) covalently attached to drugs (pegylation) is known to improve the efficiency of many drugs. Using as a test agent the novel phospho-ibuprofen (PI), we examined whether pegylation of PI could abrogate its hydrolytic degradation by esterases; PI, known to inhibit colon cancer ...

Journal: :Drug Delivery and Translational Research 2013

Journal: :Biochemical and Biophysical Research Communications 1998

Journal: :Proceedings of the National Academy of Sciences of Belarus, Chemical Series 2018

Journal: :Nanomedicine 2011
Jesse V Jokerst Tatsiana Lobovkina Richard N Zare Sanjiv S Gambhir

Nanoparticles are an essential component in the emerging field of nanomedical imaging and therapy. When deployed in vivo, these materials are typically protected from the immune system by polyethylene glycol (PEG). A wide variety of strategies to coat and characterize nanoparticles with PEG has established important trends on PEG size, shape, density, loading level, molecular weight, charge and...

Journal: : 2023

Currently no therapy of acute lymphoblastic leukemia is conceivable without L-asparaginase drugs, with its antileukemic effect by extracellular asparagine depletion, thus preventing admission to leukemic cell. Besides high antitumor effect, drugs have side and toxic effects, such as hypersensitivity reactions, thrombosis, pancreatitis / pancreatic necrosis, hepatotoxicity. For safety profile im...

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