Etoposide, a widely used anticancer drug, exhibits low and variable oral bioavailability mainly because of being substrate for the efflux transporter, P-glycoprotein (P-gp). Therefore, the present study was aimed to investigate the effect of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) and PEG 400 as P-gp inhibitors on the intestinal absorption of etoposide. Everted sacs of rat smal...

Nanosilver (AgNPs) can be synthesized using plant extracts that safe, simple, and environmentally friendly. Sweet orange contains flavonoids citric acid, which a bioreductor capping agent in silver biosynthesis to increase antimicrobial activity. AgNPs are then dispersed gel for acne treatment through peel-off mask preparation. Humectants provide moisture, prevent skin irritation regulate the v...

Etoposide, a widely used anticancer drug, exhibits low and variable oral bioavailability mainly because of being substrate for the efflux transporter, P-glycoprotein (P-gp). Therefore, the present study was aimed to investigate the effect of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) and PEG 400 as P-gp inhibitors on the intestinal absorption of etoposide. Everted sacs of rat smal...

This paper solely describes about novel aliphatic polymer prepared from polyethyleneglycol (PEG 400) moieties by melt poly condensation of 1, 4- cyclohexanediol and dodecanedioic acid. The structural elucidation the obtained, were thoroughly investigated various techniques such as FTIR, NMR, DSC, TGA, XRD. polycondensation reaction was carried out presence Titanium (IV) isopropoxide catalyst. W...

Temozolomide (TMZ) is one of the most effective chemotherapeutic agents for glioblastoma multiforme, but the required high administration dose is accompanied by side effects. To overcome this problem and to further improve TMZ's efficacy, targeted delivery of TMZ by using polymeric nanoparticles has been explored. We synthesised the PLGA-PEG-FOL copolymer and attempted encapsulation of TMZ into...

Microemulsions are an intriguing method for delivering poorly soluble drugs, protecting labile controlling drug release, and increasing bioavailability. They can be given topically, orally, or intravenously, use polyethylene glycol (PEG-400) as a co-surfactant to improve the solubility stability of biological classification system (BCS) class II drugs. The goal this research is develop test oil...

The response surface methodology (RSM) including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux. The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS), Eudragit RL 100 (ERL) and polyvinylpyrrolidone K30 (PVP), plasticizers (PEG 400), and drug. In addition, using terpenes as enhancers could increa...

The synthesis of the azoxybenzenes by the reduction of nitroarenes with reducing agent potassium borohydride in water was reported for the first time. PEG-400 was used as a phase transfer catalyst and could effectively catalyze the reduction. The electronic effects of substituent groups play an important role in determining the reduction efficiencies. Electron-withdrawing substituents promote t...