Fluoroquinolones (FQs) are extensively used in bacterial keratitis and other intraocular infections. Since eye is constantly exposed to light, incidence of ocular phototoxicity due to commonly used FQs is of great interest for their safe use. Phototoxicity of commonly used FQs (ciprofloxacin, lomefloxacin, pefloxacin, ofloxacin, sparfloxacin and gatifloxacin), has been evaluated by using HET-CA...

The in vitro activity of sparfloxacin (AT-4140; RP 64206), a new fluoroquinolone, was compared with those of 10 other agents against 1,222 clinical isolates. Sparfloxacin and ciprofloxacin were the most active quinolones against members of the family Enterobacteriaceae and nonfermenting gram-negative bacilli; sparfloxacin had superior activity against gram-positive cocci in comparison with the ...

In this study, seventy five (75) soil samples were collected from farmlands, riverbanks and dumpsites screened for the presence of Escherichia coli via inoculation on EMB, Gram’s staining some biochemical tests. Overall, 15 E. isolates identified. Dumpsite has highest number with 9(60%), followed by farmland four 4(26.7%) isolates, lastly riverbank two 2(13.3%) isolates. Subculture Sorbitol-Mac...

Staphylococcus aureus and Pseudomonas aeruginosa strains were isolated from eye swab samples randomly obtained from 100 seropositive HIV/AIDS patients who reported to various anti-retroviral treatment clinics at the University of Benin Teaching Hospital and Central Hospital both based in Benin City, Nigeria. Invitro antibiotic sensitivity patterns of strains before curing were determined by the...

The aim of this study is to phenotypically characterize Klebsiella isolates from rats. A survey  was  conducted on 100 swaps samples  obtained  from  captured  house  rats  in University Abuja main campus May August 2021. Isolation and identification the species was done using conventional cultural biochemical techniques. Of samples analyzed, 20 (20%) wer...

Fluoroquinolones are a family of broad spectrum, systemic antibacterial agents that have been used as therapy for infections in the respiratory and alimentary tract animals. The pharmacodynamic this class is widely described, predominantly to commercial drugs ciprofloxacin (CIP), enrofloxacin (ENR), pefloxacin (PEF). Bovine serum albumin (BSA) main endogenous carrier bovine bloodstream, being r...