BACKGROUND AND PURPOSE Proton radiotherapy has been increasingly utilized to treat pediatric brain tumors, however, limited information exists regarding radiation necrosis among these patients. Our aim was to evaluate the incidence, timing, clinical significance, risk factors, and imaging patterns of radiation necrosis in pediatric patients with brain tumors treated with proton radiation therap...

A small population of TSCs, which form neurospheres and possess the capacity for self-renewal, has been recently identified in adult and pediatric brain tumors. They differentiate into phenotypically diverse populations, including neuronal, astrocytic, and oligodendroglial cells in vitro and recapitulate original tumors in vivo. The understanding of brain TSCs has been greatly advanced by the k...

Abstract Brain and central nervous system tumors represent the most common childhood solid tumors. Comprising 21% of all pediatric cancers, they remain leading cause cancer-related mortality morbidity in childhood. Due to advances neurosurgical technique, radiotherapy use combination therapy, survival rates have generally increased. However, by lesion itself, its surgical removal subsequent tre...

Aberrant activation of the Hedgehog (Hh) pathway leads to development several tumors, including medulloblastoma (MB), most common pediatric brain malignancy. Hh inhibitors acting on GLI1, final effector signaling, offer a valuable opportunity overcome pitfalls existing therapies treat Hh-driven cancers. In this study, toxicity, delivery, biodistribution, and anticancer efficacy Glabrescione B (...

nowadays brain tumors remain as a significant cause of morbidity and mortality and are often treatment refractory. the grading of brain tumor has an important implication in clinical management. currently, magnetic resonance spectroscopy (mrs) is an important modality in evaluating and grading brain tumors. the aim of this study is  evaluation of metabolites in the differentiation of brain tumo...