BACKGROUND & OBJECTIVE 5-Aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is a new ablation treatment for tumors, while its function mechanism in cervical cancer is unclear. This study was to investigate the effects of ALA-PDT on cervical cancer cell lines. METHODS The effects of ALA-PDT on proliferation of 8 human cervical cancer cell lines were examined by MTT assay to find out t...

Photodynamic therapy (PDT) elicits both apoptotic and necrotic responses within treated tumors and produces microvascular injury leading to inflammation and hypoxia. PDT also induces expression of angiogenic and survival molecules including vascular endothelial growth factor, cyclooxygenase-2 (COX-2), and matrix metalloproteinases. Adjunctive administration of inhibitors to these molecules impr...

Dynamic positron emission tomography (PET), combined with constant infusion of 2-deoxy-2-[(18)F]fluoro-d-glucose (FDG), enables real-time monitoring of transient metabolic changes in vivo, which can serve to understand the underlying physiology. Here we investigated characteristic changes in the tumour FDG-uptake profiles in relation to acute localized inflammatory responses induced by photodyn...

Photodynamic therapy (PDT) is used in Europe to treat basal cell carcinoma (BCC), but it not approved the USA due uncertainties about efficacy. Vitamin D3 (VD3; cholecalciferol) treatment prior PDT improves BCC responses mice. A prospective, double-blind, crossover clinical trial [NCT03467789] was designed test whether oral VD3 pretreatment enhances response blue light PDT. Participants receive...

Photodynamic therapy (PDT) is a non-invasive treatment option for superficial basal cell carcinoma (BCC), squamous cell carcinoma (SCC) in situ or Bowen’s disease (BD), and actinic keratoses (AK). One of the advantages of PDT is the possibility to treat field cancerization. PDT is also suitable to use when treating poor healing areas such as the lower extremities. Furthermore, PDT offers an exc...

Background: The persistence of microorganisms in the root canal system is one leading causes treatment failure. Biofilms putative pathogens hidden inside dentin tubules and other ramifications may limit current disinfection protocols. Photodynamic therapy (PDT) with a wavelength 628 nm can be used as an antimicrobial strategy that uses low-power laser energy to activate non-toxic photosensitize...

Photodynamic therapy (PDT) is a promising cancer treatment. PDT uses photosensitizers that are selectively retained in malignant tumors. When tumors, pretreated with the photosensitizer, are irradiated with visible light, a photochemical reaction occurs and tumor cells are destroyed. Oxygen molecules in their metastable singlet delta state, O2(∆), are believed to be the species that destroys ca...

Although photodynamic therapy (PDT) is an established modality for cancer treatment, current dosimetric quantities, such as light fluence and PDT dose, do not account for the differences in PDT oxygen consumption for different fluence rates ( ? ). A macroscopic model was adopted to evaluate using calculated reacted singlet oxygen concentration ( [ O 2 1 ] rx ) to predict Photofrin-PDT outcome i...

In addition to established indications in non-melanoma skin cancer in immunocompetent patients, photodynamic therapy (PDT) has been studied for the treatment, and possible prevention, of superficial skin cancers in immunosuppressed patients. As a topical photosensitizer can be applied over large areas, PDT is also increasingly used for field cancerization in photodamaged skin, with evidence of ...

Photodynamic therapy (PDT) is a tumor-ablative and function-sparing oncologic intervention. The relative simplicity of photosensitizer application followed by light activation resulting in the cytotoxic and vasculartoxic photodynamic reaction has allowed PDT to reach a worldwide audience. With several commercially available photosensitizing agents now on the market, numerous well designed clini...