Purpose: Immunotherapies targeting programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) demonstrate encouraging antitumor activity and manageable tolerability in non-small cell lung cancer (NSCLC), especially in patients with high tumor PD-L1 expression, as detected by companion or complementary diagnostic assays developed for individual agents. A laboratory is unlikely to ...

When starved wild-type amoebae of Dictyostelium discoideum were washed and incubated in 1 mM-EGTA, their ability to induce soluble cyclic AMP phosphodiesterase (PD) activity in response to either millimolar cyclic AMP or a series of nanomolar cyclic AMP pulses was reduced by 55-75%. Supplementation of EGTA-treated cells with exogenous Ca2+ stimulated PD induction in a dose-dependent fashion (EC...

This work aims at providing insight into the deactivation mechanism of Pd-based membranes in propane dehydrogenation processes. Thermogravimetric analysis (TGA) experiments were conducted to study adsorption and coking propylene over conventional thin layer (TL) double-skinned (DS) under several operating conditions. A mechanistic monolayer-multilayer coke growth model was selected mathematical...

This study proposes the steam reforming of a synthetic biogas stream containing 200 ppm H2S, carried out in non-commercial supported Pd–Au/Al2O3 membrane reactor (7–8 ?m selective layer thickness) at 823 K and 150 kPa over Rh(1%)/MgAl2O4/Al2O3 catalyst. system is able to recover almost 80% total hydrogen produced during reaction shows good resistance H2S contamination, as confirmed by stable me...

BACKGROUND The increasing incidence and poor outcome associated with MPM requires finding effective treatment for this disease. PD1/PD-L1 pathway plays a central role in tumor immune evasion and appears to be predictive and prognostic marker. PD-L1 is expressed in many different human cancers but its role in MPM has yet to be established. The aim of this study is to evaluate the expression of P...

BACKGROUND The potential risk for transmission of hepatitis C virus (HCV) by peritoneal dialysis (PD) has been studied previously, with conflicting results. METHODS To assess whether HCV crosses the peritoneal membrane, the following determinations were performed in 16 patients (7 males, 9 females; mean age 41.8 years; mean time on PD 14 +/- 15 months) undergoing PD: serum anti-HCV using seco...

The permeance of Pd–Cu alloys containing 40, 53, 60, and 80 wt.% Pd has been determined over the 623–1173 K temperature range for H2 partial pressure differences as great as 2.6 MPa. Pure palladium and copper membranes were also evaluated. The Pd–Cu alloys exhibited predictable permeances that reflected the crystalline phase structures as shown in the binary phase diagram. Under conditions of f...