Paracoccidioidomycosis (PCM) is a systemic mycosis endemic to Latin America. Brazil accounts for approximately 80% of cases, where it represents a major public health issue due to its disabling impact and the number of premature deaths it causes. We present a retrospective cohort study that was conducted in order to better understand factors that relate to cure of the infection in the treatment...

HIV-1 protease is one of the main therapeutic targets in HIV. However, a major problem in treatment of HIV is the rapid emergence of drug-resistant strains. It should be particularly helpful to clinical therapy of AIDS if one method can be used to predict antivirus capability of compounds for different variants. In our study, proteochemometric (PCM) models were created to study the bioactivity ...

BACKGROUND Centrosomes, the major organizers of the microtubule network in most animal cells, are composed of centrioles embedded in a web of pericentriolar material (PCM). Recruitment and stabilization of PCM on the centrosome is a centriole-dependent function. Compared to the considerable number of PCM proteins known, the molecular characterization of centrioles is still very limited. Only a ...

The thermally dimorphic fungus Paracoccidioides brasiliensis (Pb) is the causative agent of paracoccidioidomycosis (PCM), one of the most frequent systemic mycosis that affects the rural population in Latin America. PCM is characterized by a chronic inflammatory granulomatous reaction, which is consequence of a Th1-mediated adaptive immune response. In the present study we investigated the mech...

Centrosomes consist of a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Proteins that contain a Pericentrin/AKAP450 centrosomal targeting (PACT) domain have been implicated in recruiting several proteins to the PCM. We show that the only PACT domain protein in Drosophila (the Drosophila pericentrin-like protein [D-PLP]) is associated with both the centrioles and th...

Phase change memory (PCM) as a newly developed storage medium has many attractive properties such as non-volatility, byte addressability, high density and low energy consumption. Thus, PCM can be used to build non-volatile main memory databases. However, PCM’s long write latency and high write energy bring challenges to PCM-based memory systems. In this paper, we propose an improvement over the...

Nowadays, many applications use spatial data for instance-location information, so storing spatial data is important. We suggest using R -Tree over PCM. Our objective is to design a PCM-sensitive R -Tree that can store spatial data as well as improve the endurance problem. Initially, we examine how R -Tree causes endurance problems in PCM, and we then optimize it for PCM. We propose doubling th...

We describe a new architecture for passive robots and haptic displays, which we call a programmable constraint machine (PCM). An n-dof PCM can, under computer control, exhibit constraints (smooth, impenetrable virtual surfaces of dimensionality < n), or it can allow free n-dof motion. At the heart of the PCM is a nonholonomic element, which is used as a continuously variable transmission (CVT)....

Phase change memory (PCM) is the best candidate device among next generation random access memory technologies. PCM has a potential to replace Flash memory due to non-volatility and in-place programmability, and low power consumption. Even though lifetime of PCM is longer than flash memory, wear leveling is needed because of non-uniformity of storage workload or malicious attack. In this paper,...

The dot immunobinding assay, a rapid, visually read test, was adapted for serodiagnosis and follow-up of paracoccidioidomycosis (PCM). Purified gp43 antigen was tested before and after sodium metaperiodate treatment. To evaluate the assay, it was tested with sera from PCM, histoplasmosis, Jorge Lobo's disease, aspergillosis, candidiasis, and cryptococcosis patients and healthy subjects. Native ...