Psoriasis is associated with atherosclerosis, in which circulating microparticles play an important role. In severe psoriasis, there was an increase of endothelial- and platelet- microparticles which could be decreased by anti-TNFα. However, whether anti-IL-12/23 treatment would decrease the level of microparticles remains unknown. Our study showed that, despite the clinical improvement of psor...

Methods The study was performed on 54 patients admitted to Matei Bals Institute Bucharest, between January 2010 July 2010, out of which 30 women and 24 men aged 21-64 years. 14 patients were diagnosed with HIV stage C3(CDC criteria), 11 with HBV and 14 with HCV infection, while 15 were healthy controls. We assessed the plasma level of 25-OHD(nmol/L, Elisa kit, Immunodiagnostic Systems), IFN g, ...

COVID-19 has had severe consequences worldwide. It been estimated that the contribution of genetic factors to disease is about 50%. The A16974C polymorphism IL-12 p40 gene described as being related resistance or susceptibility other infectious diseases; therefore, it likely can also be COVID-19. objective this study was describe relationship between IL12 with clinical forms in Cuban patients. ...

OBJECTIVES To understand key characteristics of the leadership team, and to examine if differences in these factors exist between for-profit (FP) and not-for-profit (NFP) nursing homes (NHs). DESIGN Cross sectional. SETTING US nursing homes. PARTICIPANTS A nationally representative sample of 1174 US NHs conducted in 2004. INTERVENTION N/A. MEASUREMENTS Reported data on tenure, educati...

Six volunteers experienced severe inflammatory response during the Phase I clinical trial of a monoclonal antibody that was designed to stimulate a regulatory T cell response. Soon after the trial began, each volunteer experienced a "cytokine storm", a dramatic increase in cytokine concentrations. The monoclonal antibody, TGN1412, raised serum concentrations of both pro- and anti-inflammatory c...

Type 1 diabetes (T1D) is a metabolic disease that is initiated by the autoimmune destruction of pancreatic insulin-producing beta cells that is accompanied by the development of antigen-specific antibodies and cytotoxic T lymphocytes (CTLs). Several studies have shown that vaccination with diabetic autoantigens provides some protection against this process. In this report we describe a new oral...