Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants in consumer goods, such as plastics, electronics, textiles, and construction material. PBDEs have been found in human milk, fat, and blood samples. Rodent studies indicate that PBDEs may be detrimental to neurodevelopment, possibly by lowering thyroid hormone concentrations in blood. In the present study, we determined c...

BACKGROUND Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in many household items. Given concerns over their potential adverse health effects, we identified predictors and evaluated temporal changes of PBDE serum concentrations. METHODS PBDE serum concentrations were measured in young children (2-8 years old; N = 67), parents of young children (<55 years old; N = 90), and...

BACKGROUND Prenatal polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) exposures may influence children's neurodevelopment. OBJECTIVE We examined the association of prenatal PBDE and PCB exposures with children's reading skills at ages 5 and 8 years, Full-Scale Intelligence Quotient (FSIQ), and externalizing behavior problems at age 8 years. METHODS From 239 mother-...

Artan nüfus ve kentleşme beraberinde birçok hava kirliliğini getirmekte bunun sonucunda bronşit, astım, kalp krizi, akciğer hastalığı, kanser erken ölüm gibi kirliliğinin neden olduğu hastalıklara olmaktadır. İnsanlar, özellikle kentsel alanlarda yaşayanlar, zamanlarının %90'ından fazlasını iç mekanlarda geçirdikleri için, son zamanlarda dış ortam havasının yanı sıra kalitesine de dikkat çekmey...

Polybrominated diphenyl ethers (PBDEs) have been identified in every compartment of the environment and biota due to their widespread use as flame retardants. There is debate over their potential to threaten environmental and human health due to insufficient toxicological information. The weak to moderate binding affinity of PBDE congeners to the Ah receptor (AhR) and the weak induction of EROD...

BACKGROUND Polybrominated diphenyl ethers (PBDEs) reduce blood concentrations of thyroid hormones in laboratory animals, but it is unclear whether PBDEs disrupt thyroid hormones in pregnant women or newborn infants. OBJECTIVES We investigated the relationship between maternal PBDE levels and thyroid hormone concentrations in maternal and cord sera. METHODS We used data from the Health Outco...

BACKGROUND Polybrominated diphenyl ethers (PBDEs) are lipophilic flame retardants that bioaccumulate in humans. Child serum PBDE concentrations in California are among the highest worldwide. PBDEs may be associated with obesity by disrupting endocrine systems. OBJECTIVE In this study, we examined whether pre- and postnatal exposure to the components of pentaBDE mixture was associated with chi...

Polybrominated diphenyl ethers (PBDEs) are popular flame-retardants which are highly hydrophobic and ubiquitous in the environment. Elevated concentrations of PBDEs have been found in biosolids and in agricultural soils that have received biosolids in Europe and North America over the last 5 years. A study was carried out to confirm the contamination of soil by PBDEs due to biosolids applicatio...

Previous studies have described high levels of polychlorobiphenyls (PCB), polybrominated diphenylether (PBDE), toxaphene, p,p'-dichlorodiphenyltrichloroethane (DDT), and p,p'-dichlorodiphenyldichloroethylene (DDE) in the blubber of the harbour porpoise from the North Sea raising the question of a potential endocrine disruption in this species. In the present study, the thyroids of 57 harbour po...

BACKGROUND Little is known about the rates of loss (depuration) of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) from mothers during lactation. Depuration rates affect infant exposure to chemicals during breast-feeding, and fetal and lactational transfers during subsequent pregnancies. OBJECTIVE Our objective in this study was to estimate depuration rates of PBDE...