Adipose tissue has the largest capacity to store energy in the body and provides energy through the release of free fatty acids during times of energy need. Different types of immune cells are recruited to adipose tissue under various physiological conditions, indicating that these cells contribute to the regulation of adipose tissue. One major pathway influenced by a number of immune cells is ...

Preclinical models of restenosis are essential to unravel the pathophysiological processes that lead to in-stent restenosis and to optimize existing and future drug-eluting stents. A variety of antibodies and transgenic and knockout strains are available in rats. Consequently, a model for in-stent restenosis in the rat would be convenient for pathobiological and pathophysiological studies. In t...

In this paper, we describe an implementation of qualitative physiology in the field of cardiac emergencies, which is integrated to a 3D virtual patient. . The system integrates qualitative simulation techniques with a realistic visual simulation of the patient in a 3D environment representing an ER room. We have adapted Qualitative Process Theory (QPT) to the representation of physiological pro...

In the last decade, proteomics and metabolomics have contributed substantially to our understanding of cardiovascular diseases. The unbiased assessment of pathophysiological processes without a priori assumptions complements other molecular biology techniques that are currently used in a reductionist approach. In this review, we highlight some of the "omics" methods used to assess protein and m...

Amyotrophic lateral sclerosis is an inexorably progressive neurodegenerative disorder involving the classical motor system and the frontal effector brain, causing muscular weakness and atrophy, with variable upper motor neuron signs and often an associated fronto-temporal dementia. The physiological disturbance consequent on the motor system degeneration is beginning to be well understood. In t...

This paper presents a new non-invasive biomedical monitoring of selected psychosomatic processes. The proposed method measures human skin conductivity using the interdigitated array (IDA) microelectrodes, which allow continual monitoring and analysis of complicated physiological, pathophysiological, and therapeutic processes. The main goal is monitoring of psycho-galvanic reflex of the human sk...

Generation of the pleiotropic sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by su...

Acute or chronic abdominal pain can be the result of many different pathophysiological processes. Many presentations are due to benign processes, whereas others may be life threatening if not recognised swiftly. Among the many possible causes, clinicians need to consider the possibility of intestinal ischaemic disorders. The variable vessels involved, location of bowel affected, and different l...