27 Several mutant mouse models for human diseases such as diabetes mellitus have been 28 generated in the large-scale Munich ENU (N-ethyl-N-nitrosourea) mouse mutagenesis project. 29 The aim of this study was to identify the causal mutation of one of these strains and to 30 characterize the resulting diabetic phenotype. Mutants exhibit a T to G transversion mutation 31 at nt 629 in the glucokin...

BACKGROUND Complex anatomy of intra-cardiac structures requires spatial orientation of image in three dimensions for better understanding and enhanced image interpretation. We evaluated the feasibility and efficacy of the emerging 'real-time three-dimensional transthoracic echocardiography' technique for comprehensive assessment of cardiac anatomy, physiology, pathomorphology and pathophysiolog...

BACKGROUND The objective of this study was to evaluate the synthesis and biocompatibility of Fe₃O₄ nanoparticles and investigate their therapeutic effects when combined with magnetic fluid hyperthermia on cultured MCF-7 cancer cells. METHODS Magnetic Fe₃O₄ nanoparticles were prepared using a coprecipitation method. The appearance, structure, phase composition, functional groups, surface charg...

The macro- and microscopic structure of the lungs mature rabbits – Oryctolagus cuniculus L., 1758 European rabbit was studied. This work performed using comprehensive research methods: anatomical, organometric, histological histometric. carried out in conditions laboratory pathomorphology Department Anatomy Histology. scientific on subject Histology Polissya National University theme: “Developm...

Aim. To reveal relation of change in intraoperative electroencephalography (EEG), electrocorticography (EсoG) with age patients, the anamnesis duration, localization and type pathology, result treatment. Materials methods. 64 patients symptomatic epilepsy operated at N.N. Burdenko National Medical Research Center Neurosurgery Ministry Health Russia from 2010 to 2016. 28 males, 36 females, 3 mon...

Studies were made on the oncogenic response of 3086 young chicks to i.v. inoculation of MC29 avian leukosis virus from blood plasma of previous-passage birds or the supernatant fluid of cultures of chick embryo cells infected with strain MC29. Among the large variety of neoplasms of other tissues previously described, there occurred a high incidence of primary growths of the liver. Pathomorphol...

The aim of the present study was to assess the clinicopathological features and prognostic factors of primary small gastrointestinal stromal tumors (GISTs) outside the stomach. The clinical data, clinicopathological features and prognostic factors of 20 patients with a pathologically-confirmed diagnosis of non-gastric GIST that were treated at Liaoning Cancer Hospital & Institute between July 2...

BACKGROUND Pulmonary vascular structure remodeling (PVSR) is a hallmark of pulmonary hypertension. P27(kip1), one of critical cyclin-dependent kinase inhibitors, has been shown to mediate anti-proliferation effects on various vascular cells. Beta-estradiol (β-E2) has numerous biological protective effects including attenuation of hypoxic pulmonary hypertension (HPH). In the present study, we em...

Compliance with medication but not structural MRI measures predict functional outcome in first-episode schizophrenia patients Dear Editors, In longitudinal studies in schizophrenia a variety of clinical variables were consistently associated with symp-tomatological and functional outcome including gender, age and mode of illness-onset, duration of untreated psychosis, compliance with and respon...