The effector SnTox3 from Parastagonospora nodorum elicits a strong necrotic response in susceptible wheat and also interacts with pathogenesis-related protein 1 (TaPR-1), although the function of this interaction disease is unclear. Here, we dissect TaPR1 by studying SnTox3–TaPR1 demonstrate dual functionality SnTox3. We utilized site-directed mutagenesis to identify an variant, SnTox3P173S, th...

Age-related macular degeneration (AMD) is a complex, degenerative and progressive chronic disease that leads to severe visual loss. The prevalence of early AMD accounts for 18% in the population between 65 74 years age even 30% subjects older than years. articles published last decade point out significant role oxidative stress onset development age-related degeneration. Generally, reactive oxy...

Alzheimer’s disease (AD) is a degenerative of central nervous system, which seriously threatens the life and health elderly people. It has been for long time that Traditional Chinese medicine (TCM) treatment AD effective. This study analyzed potential target molecular mechanism most often used drug pair Astragalus membranaceus Acorus tatarinowii to treat by network pharmacological method. First...

Viroporins are involved in viral pathogenesis, play an important role the morphogenesis of virions and ensure their release from infected cell. These proteins potentially promising as possible targets for regulation virus reproduction. The literature data on current understanding coronavirus viroporins functioning summarized review. Special attention is focused specific structural features that...

Though the essential role of extracellular matrix in biofilm development has been extensively documented, the function of matrix-associated proteins is elusive. Determining the dynamics of matrix-associated proteins would be a useful way to reveal their functions in biofilm development. Therefore, we applied iTRAQ-based quantitative proteomics to evaluate matrix-associated proteins isolated fro...