BACKGROUND The surgical management of cholesteatoma is a controversial issue, particularly regarding intact-canal-wall mastoidectomy (ICWM) versus canal-wall-down mastoidectomy (CWDM). The current experiment compared the quality of visualization in different middle ear structures using ICWM with otoendoscopy with findings of CWDM by microscopy. MATERIALS AND METHODS The patients diagnosed wit...

OBJECTIVES To investigate the pathogenesis of one of the most troublesome conditions following ear surgery, a middle-ear cavity problem. METHODS Keratinocyte growth factor (KGF) and its receptor (KGFR), the ratio of proliferating epithelial cells using Ki-67, and the extent of infiltration of B cells and T cells were examined immunohistochemically in 10 ears with a cavity problem, 70 ears wit...

We report here on a case of congenital cholesteatoma that extended into the internal auditory meatus and cochlea. A 17-year-old boy underwent surgery for a very large cholesteatoma, which was discovered behind an intact tympanic membrane. Pure tone audiometry revealed an unresponsive ear. High resolution temporal bone computed tomography showed perilabyrinthine extension with its absence in the...

OBJECTIVE : Management of pediatric cholesteatomas remains controversial. We reviewed our 16-year experience in the surgical treatment of cholesteatomas in children and describe a treatment paradigm. STUDY DESIGN : The authors conducted a retrospective review. METHODS : A total of 106 mastoidectomies (86 for an acquired cholesteatoma and 20 for a congenital cholesteatoma) were performed in ...

OBJECTIVES Cholesteatoma destructs bony tissue by the interactions between hyperproliferative epithelial cells and subepithelial inflammatory cells. The aim of this study was to evaluate the expression of epidermal growth factor receptor (EGFR) and microvessel density (MVD) in middle ear cholesteatoma tissue in an effort to determine the relationship between expression of EGFR and neovasculariz...

OBJECTIVE The aim of this study was to evaluate the diagnostic accuracy of echo-planar diffusion-weighted magnetic resonance imaging (EP-DWI) and high-resolution computed tomography (HRCT) in the detection and localization of cholesteatoma. MATERIALS AND METHODS Fifty-four patients were prospectively included in this study. Patients with suspected primary or residual cholesteatoma were evalua...

The existence of acquired cholesteatoma has been recognized for more than three centuries; however, the nature of the disorder has yet to be determined. Without timely detection and intervention, cholesteatomas can become dangerously large and invade intratemporal structures, resulting in numerous intra- and extracranial complications. Due to its aggressive growth, invasive nature, and the pote...

OBJECTIVE To examine 10-year results of canal wall down mastoidectomy (CWDM) for acquired cholesteatoma. METHODS Medical records of 136 patients with cholesteatoma who has undergone CWDM in a university hospital and who had a follow-up of at least 10 years were checked. RESULTS During follow-up, 21% of patients had undergone one revision operation and 3% two revisions. The recurrence rate o...

Edfeldt, L. 2013. Middle Ear Cholesteatoma: Surgical Treatment, Follow-up and Hearing Restoration. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 905. 48 pp. Uppsala. ISBN 978-91-554-8672-3. Although middle-ear cholesteatoma is a major topic in otological research, its etiology and pathogenesis remain unclear. Pediatric chol...

Background: Keratinocytes are the predominant cell type in a cholesteatoma, and microRNA (miR)-203a has been shown to be essential for the growth and differentiation of keratinocytes. The regulatory mechanisms of miR-203a and Bmi1-the predicted target of miR-203a that is associated with cholesteatoma-have not been clarified. Methods: Real-time PCR and western blot were carried out for the detec...