Objective: To compare the clinical efficacy of gabapentin, an anticonvulsant agent, and paroxetine, a selective serotonin reuptake inhibitor in management post-menopausal symptoms. Methods: In this trial, two groups patients with menopause who had hot flashes were included. One group received gabapentin (600 mg daily, 23 cases) for 8 weeks. The other paroxetine (one capsule daily at morning or ...

CONTEXT The generalized type of social phobia (social anxiety disorder) is a severe and often disabling form of social anxiety that affects approximately 5% of the general population. Earlier research has shown monoamine oxidase inhibitors or benzodiazepines to be effective in treating this condition, but neither has achieved widespread use. OBJECTIVE To compare the efficacy of paroxetine, a ...

Clinical Problem Ms P, a 38-year-old woman, is receiving tamoxifen for breast cancer. She has clinically significant anxiety and depression. She also suffers from tamoxifenrelated hot flashes. Paroxetine is an effective treatment for anxiety,1 depression,2 and menopausal hot flashes,3 including those related to tamoxifen.4 What are the concerns regarding the use of paroxetine (or other antidepr...

serotonin specific reuptake inhibitors (ssri) may induce antinociception however, the mechanism of this effect is not clear. ssrls increase 5-ht levels in neuronal synapses and facilitate serotonergic activity. in this study, therefore, the activity of para-chlorophenylalanine (pcpa), which reduces 5-ht release, and 5- hydroxy tryptophan (5-htp), a precursor of 5-ht, were examined on the antino...

This article addresses the management of depression in primary care from the perspective of a health maintenance organization. The rise of managed care systems is briefly discussed with reference to their impact on choice of treatment strategies. Cost-effectiveness considerations pertinent to a health maintenance organization are reviewed. A simplified protocol for the treatment of depression w...

INTRODUCTION This study compares the differential efficacy of three groups of treatments for agoraphobia: paroxetine combined with cognitive-behavioral therapy, paroxetine combined with cognitive-behavioral therapy and virtual reality exposure, and a group with only paroxetine. METHODOLOGY 99 patients with agoraphobia were finally selected. Both combined treatment groups received 11 sessions ...