objective: parkinson's disease (pd) is one of the most common neurodegenerative disorders which is characterized by tremor, rigidity, bradykinesia and postural disturbances. studies indicate that grape juice and exercise may have beneficial effects on neurodegenerative disorders. therefore, in the present study, we evaluated the effects of red grape juice (gj) together with treadmill runni...

Migraine is a neurovascular disorder that is characterized by unilateral, pulsatile headaches. Migraine due to its individual and social effects is known as a major cause of disability in the world. The main complication of this disease is chronification that is known as chronic migraine (CM). It seems that several factors contribute to migraine chronification such as age, female gender, obesit...

introduction: parkinson`s disease (pd) is a chronic disorder of basal ganglia with cardinal signs of resting tremor, bradykinesia, rigidity and postural instability. various studies have evaluated quiet stance postural stability in mild pd but as the authors know there is no consensus on this issue. therefore, the aim of this study was to evaluate stance stability of the subjects at early stage...

Mitochondrial dysfunction has been implicated in the dopaminergic neurodegeneration, which characterizes Parkinson’s disease (PD). The activities of mitochondrial complexes I and IV were found to be reduced in the brains of PD patients (n = 4) as compared to age-matched controls (n = 4). This is tested in SH-SY5Y cell lines, transformed Rho0 cells, and in normal and PD cybrid cell lines. Cybrid...

Mitochondrial dysfunction has been implicated in the dopaminergic neurodegeneration, which characterizes Parkinson’s disease (PD). The activities of mitochondrial complexes I and IV were found to be reduced in the brains of PD patients (n = 4) as compared to age-matched controls (n = 4). This is tested in SH-SY5Y cell lines, transformed Rho0 cells, and in normal and PD cybrid cell lines. Cybrid...

parkinson’s disease (pd) is a rather common movement disorder as a result of the degeneration of dopaminergic neurons within the substantianigra. current treatments for pd afford symptomatic relief with no prevention of disease progression. due to the neuroprotective and anti-apoptotic potential of the isoquinoline alkaloid berberine (bbr), this study was conducted to assess whether bbr pretrea...

Dysarthric Speech Recognition and Offline Handwriting Recognition using Deep Neural Networks Suhas Pillai, M.S. Rochester Institute of Technology, 2017 Supervisor: Dr. Raymond Ptucha Millions of people around the world are diagnosed with neurological disorders like Parkinsons, Cerebral Palsy or Amyotrophic Lateral Sclerosis. Due to the neurological damage as the disease progresses, the person s...

Introduction: Freezing of gait, a common PD motor symptom, could increase the risk of falling. This study aimed to investigate the clinimetric attributes of the Freezing of Gait Questionnaire (FOGQ) for people with Parkinson disease in the “off” state. Methods: A total of 115 patients with Parkinson disease (PD; mean age, 60.25 years) were included. Acceptability, internal consistency (by the ...