SUMMARY The functional imaging technique most widely used in European clinics to differentiate a true parkinsonian syndrome from vascular parkinsonism, drug-induced changes, or essential tremor is dopamine-transporter SPECT. This technique commonly reports dopamine-transporter function, with decreasing striatal uptake demonstrating increasingly severe disease. The strength of dopamine-transport...

Tardive dyskinesia can be suppressed by dopaminergic receptor blockers, but often at the cost of a reciprocal increase in Parkinsonism. Oxiperomide, a dopaminergic antagonist that has been shown to reduce levodopa-induced dyskinesias without producing an equal aggravation of Parkinsonism, was evaluated in a blind placebo-controlled trial in 10 patients with tardive dyskinesia. It decreased tard...

A syndrome similar to idiopathic parkinsonism developed after intravenous self-administration of an illicit drug preparation in which N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) might have been responsible for the toxicity. In the present study we show that intravenous administration of NMPTP to the rhesus monkey produces a disorder like parkinsonism (akinesia, rigidity, postural tremo...

Neurological complications of Lyme disease include meningitis, encephalitis, dementia, and, rarely, parkinsonism. We present a case of striatonigral degeneration, a form of multiple system atrophy, in Lyme-associated parkinsonism. A 63-year-old man presented with erythema migrans rash, joint pains, and tremors. Serum and cerebrospinal fluid antibodies and polymerase chain reaction for Borrelia ...

Changes in myelin ultrastructure under experimental Parkinsonism the tissues of medulla oblongata and striatum were performed induced by rotenone administration 30 adult rats Wistar line. Clinico-electromyographic studies on patients with Parkinson's disease a stage 2.0 -3.0 (Hoehn a. Yahr). Efficacy Cerebrolysin has been shown to correct abnormalities elucidate effect muscle reflex response ir...

Recent studies have suggested a high incidence of atypical parkinsonism in patients living in or coming from different “exotic” areas.1–3 In some cases, environmental factors have been suspected, including the consumption of tropical fruits of the Annonaceae family containing alkaloids with possible neurological toxicity.1,4,5 Three Annonaceae fruits (Annona muricata, A. squamosa, and A. reticu...