We have developed an effective analytical method to determine the concentration of paraquat in human plasma by high-performance liquid chromatography (HPLC), which can provide methodological support for diagnosis, therapy, and prognostic evaluation of acute poisoning related to paraquat. The plasma samples were deproteinized with 35% perchloric acid. Then the paraquat was extracted from the sam...

The effect of betanin on a rat paraquat-induced acute lung injury (ALI) model was investigated. Paraquat was injected intraperitoneally at a single dose of 20 mg/kg body weight, and betanin (25 and 100 mg/kg/d) was orally administered 3 days before and 2 days after paraquat administration. Rats were sacrificed 24 hours after the last betanin dosage, and lung tissue and bronchoalveolar lavage fl...

Paraquat (1, 1’ dimethyl 4,4’ dipyridylium) is a highly toxic chemical herbicide or week killer. It one of the most common herbicides used today, but it can cause fatal poisoning when ingested inhaled. often difficult to diagnose in face non specific clinical features. Although freely available herbicide, few cases have been reported from India. We case paraquat at Hindu Rao Hospital and NDMC M...

AIM To evaluate the effects of aqueous extract of Salep on Paraquat-mediated liver injury. METHODS In this experimental study, 56 adult male Wistar rats were divided randomly to 7 groups as control, sham, and 5 experimental groups. In control group, rats did not receive any substance during experiment. In Sham group, rats were given distilled water according to their body weight and in experi...

We have studied the effects of paraquat (methyl viologen), a herbicide that increases intracellular production of Superoxide radical, on the viability of virus-transformed and nontransformed normal rat kidney (NRK) cells in culture. We have shown that a low concentration of paraquat (12.5 /UM)is cytotoxic toward virus-transformed cell lines, including Kirsten sar coma virusand SV40-transformed ...

Abstract Even though paraquat is considered to be one of the most toxic herbicides, it used ones. Paraquat-based preparations are heavily across many important agricultural countries and for a lot types crops such as soya. As soya in large quantities feed production, residues products potential threat livestock. The aim this study was investigate whether intended animal contain paraquat. Theref...

Paraquat is a nonselective herbicide that has been widely used all over the world. However, because of its severe toxicity and lethal effects, its use is no longer allowed in several countries [1,2]. According to a 2008 report of toxic exposures in Korea, the most common cause of intoxication case was pesticide (30.7%), which included fungicides, herbicides, insecticides, miscellaneous pesticid...

BACKGROUND Paraquat poisoning is a lethal method of suicide used around the world. Although restricting its accessibility had been widely discussed, the underlying psychopathological mechanism of paraquat self-poisoning and its association with mortality have not yet been explicitly evaluated. METHODS We included all patients admitted to a tertiary general hospital in Taiwan between 2000 and ...

Paraquat is a toxic herbicide that may induce acute lung injury, circulatory failure and death. The present work aimed at investigating whether there is systemic inflammation and vascular dysfunction after paraquat exposure and whether these parameters were related. There was neutrophilia and accumulation of neutrophils in lung and bronchoalveolar lavage of animals given paraquat. This was asso...

Gross overproduction of the manganese-containing superoxide dismutase in Escherichia coli, by virtue of a multicopy plasmid bearing the sodA gene, decreases enumeration on paraquat-containing agar plates. This reflects growth inhibition, not lethality, since cells on these plates can be rescued by exclusion of dioxygen. Growth in liquid medium revealed that the control strain adapted to growth ...