background: we administered paracetamol and fentanyl at the beginning of phacoemulsification cataract surgery. we think that paracetamol administered alone is as effective as fentanyl in treating pain after cataract surgery with fewer side effects during operation and in post anesthesia care unit (pacu). the goal of this study was to compare to the postoperative pain relief effect of paracetamo...

A simple, accurate and sensitive high-performance liquid chromatography (HPLC) method was developed, validated and applied to the determination of either theophylline or paracetamol in milk-based samples. The method allowed drug quantification in fresh and powdered milk with a relatively short run time of analysis and it was also successfully applied to the quantification of the drugs in solid ...

INTRODUCTION The present study deals with development and validation of a simple, rapid, sensitive and economic area under curve method for simultaneous estimation of paracetamol and nabumetone in bulk and tablet dosage form. MATERIALS AND METHOD Area under curve method includes determination of area of paracetamol and nabumetone at absorption maxima, which for paracetamol was 248.8 ± 10 nm a...

Paracetamol (Acetaminophen) is one of the drugs most often prescribed to patients, ranging from children elderly, as a pain reliever by inhibiting prostaglandin synthesis in central nervous system. has broad therapeutic index with an adult dose 500-1000 mg each time, interval 4-6 hours. The review article aims compare analysis and sample preparation methods used detect paracetamol human blood, ...

Surface water and groundwater is contaminated with pseudoperistent xenobiotics present in the environment. The risk associated with an increase in the consumption of drugs and their permanent occurrence especially in the aquatic environment falls on non-target organisms. The aim of this thesis was to assess the effect of increasing concentrations of paracetamol (0.1; 10; 100 μg/l) on the growth...

In this article we describe development and validation of stability indicating, accurate, specific, precise and simple Ion-pairing RP-HPLC method for simultaneous determination of paracetamol and cetirizine HCl along with preservatives i.e. propylparaben, and methylparaben in pharmaceutical dosage forms of oral solution and in serum. Acetonitrile: Buffer: Sulfuric Acid (45:55:0.3 v/v/v) was the...

Aim: To estimate the effect of initial therapy with Paracetamol and Ketoprofen on glomerular and tubular integrity in patients with Rheumatoid arthritis (RA), to quantify the toxicity of these drugs through measurements of the enzyme excretion that correlates with the damage degree on the tubular epithelium. Microalbuminuria is used as a marker for glomerular damage, and the urinary excretion o...

BACKGROUND Autism and Autism Spectrum Disorder (ASD) are complex neurodevelopmental disorders. Susceptibility is believed to be the interaction of genetic heritability and environmental factors. The synchronous rises in autism/ASD prevalence and paracetamol (acetaminophen) use, as well as biologic plausibility have led to the hypothesis that paracetamol exposure may increase autism/ASD risk. ...

BACKGROUND Clinical practice guidelines recommend that the initial treatment of acute low back pain (LBP) should consist of advice to stay active and regular simple analgesics such as paracetamol 4 g daily. Despite this recommendation in all international LBP guidelines there are no placebo controlled trials assessing the efficacy of paracetamol for LBP at any dose or dose regimen. This study a...

UNLABELLED Worldwide, paracetamol is administered as a remedy for complaints that occur after vaccination. Recently published results indicate that paracetamol inhibits the vaccination response in infants when given prior to vaccination. The goal of this study was to establish whether paracetamol exerts similar effects in young adults. In addition, the effect of timing of paracetamol intake was...