background: adjuvants such as ketamine, promethazine and paracetamol could bring up patients satisfaction and control harmful effects of opioids besides lessening their needed doses, as seen by fentanyl/paracetamol and fentanyl/ketamine combination before. the current study headed to compare paracetamol and ketamine in addition to fentanyl applied by infusion pumps in order to pain relief follo...

results the pain score was lower in group a (p= 0.01), but the morphine consumption showed no significant difference between the groups (p= 0.24) during the first 6 hours postoperatively. conclusions although paracetamol (1gr) has caused a better pain relief quality but it is not a suitable analgesic for moderate pain control in acute phase after surgery alone. background although opioids are t...

OBJECTIVE Paracetamol /codeine has shown a strong analgesic activity in several studies conducted among different kind of subjects, including those with trauma. Nevertheless, its efficacy in patients accessing the Emergency Department (ED) for different kind of pain has never been tested. PATIENTS AND METHODS This is a cross-sectional, observational, prospective, cohort study. Inclusion crite...

Purpose: To determine the effect of the temperature of water used for the preparation of paracetamol and ascorbic acid mixture on its stability, as well as to assess the influence of humidity on the stability of single components and their mixtures. Methods: The stability of the mixtures in aqueous medium was evaluated with the aid of UV–Vis spectrophotometer interfaced with a computer. Spectra...

OBJECTIVES To identify patterns of prehospital administration of paracetamol to children who were perceived to be feverish by their carers. METHODS A prospective cohort study of carers of children attending a paediatric accident and emergency (A&E) department. Carers of children completed a questionnaire to identify domestic patterns of paracetamol use. Data were collected on temperature of t...

The effect of grapefruit juice and liqorice juice on salivary pharmacokinetics of paracetamol (acetaminophen, APAP) in 8 healthy subjects (4 males and 4 females) was investigated. Paracetamol tablet (500 mg) was administered to the volunteers with either 240 mL grapefruit juice, licorice juice or water followed by saliva samples collection at different time intervals in a sequential study desig...

Paracetamol is an important anti-inflammatory and analgesic drug widely used in biological disorders. One of major problems with this drugs is its low solubility thus dissolution rate in biological fluid, which results into poor bioavailability after oral administration. In this study polyvinyl pyrrolidone (PVP) is used to enhance bioavailability of paracetamol. Paracetamol and PVP are used in ...

Paracetamol was chosen to induce hepatotoxicity in rats. Gloriosa superba tubers were extracted and used for the treatment against paracetamol induced toxicity. In this study, the animals were divided into three groups comprising of six animals each. Group I served as a control, group II animals were administered with paracetamol(200 μg/kg) orally for 10 days, group III animals were received Gl...

A simple, specific and stability indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of paracetamol and lornoxicam in tablet dosage form. A Brownlee C-18, 5 μm column having 250×4.6 mm i.d. in isocratic mode, with mobile phase containing 0.05 M potassium dihydrogen phosphate:methanol (40:60, v/v) was used. The flow rate was 1...

BACKGROUND Current data concerning maternal paracetamol intake during pregnancy, or intake during infancy and risk of wheezing or asthma in childhood is inconclusive based on epidemiological studies. We have investigated whether there is a causal link between maternal paracetamol intake during pregnancy and lactation and the development of house dust mite (HDM) induced allergic airways disease ...